Clinical Study on Traditional Chinese Medicine for Nebulized Inhalation Combined with Retention Enema in the Treatment of Sepsis（ Syndrome of Excessive Heat of Qifen） Caused by Multidrug-Resistant Organisms

CUI Lei; XIN Xianbo; SHEN Bin; HU Qiuli; YAN Lin

doi:10.14009/j.issn.1672-2124.2021.06.010

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Clinical Study on Traditional Chinese Medicine for Nebulized Inhalation Combined with Retention Enema in the Treatment of Sepsis（ Syndrome of Excessive Heat of Qifen） Caused by Multidrug-Resistant Organisms

更新时间：2022-10-08

- Clinical Study on Traditional Chinese Medicine for Nebulized Inhalation Combined with Retention Enema in the Treatment of Sepsis（ Syndrome of Excessive Heat of Qifen） Caused by Multidrug-Resistant Organisms
- Vol. 21, Issue 6, Pages: 682-686(2021)
- 作者机构：
  
  济宁市中医院重症医学科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.06.010
  CLC： R459.7
- Published：2021，
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CUI Lei, XIN Xianbo, SHEN Bin, et al. Clinical Study on Traditional Chinese Medicine for Nebulized Inhalation Combined with Retention Enema in the Treatment of Sepsis（ Syndrome of Excessive Heat of Qifen） Caused by Multidrug-Resistant Organisms. [J]. 21(6):682-686(2021)
DOI：

CUI Lei, XIN Xianbo, SHEN Bin, et al. Clinical Study on Traditional Chinese Medicine for Nebulized Inhalation Combined with Retention Enema in the Treatment of Sepsis（ Syndrome of Excessive Heat of Qifen） Caused by Multidrug-Resistant Organisms. [J]. 21(6):682-686(2021) DOI： 10.14009/j.issn.1672-2124.2021.06.010.

摘要

目的:探讨中药雾化吸入联合保留灌肠对多重耐药菌所致脓毒症(气分实热证)的临床疗效。方法:选取2019年6月至2020年5月济宁市中医院重症医学科收治的脓毒症(气分实热证)患者90例进行前瞻性研究

采用随机数字表法进行分组

研究组和对照组各45例患者。两组患者均根据《中国严重脓毒症/脓毒性休克治疗指南》进行标准治疗

研究组患者在此基础上行青石合剂雾化吸入联合白虎汤加减保留灌肠治疗

7 d为1个疗程

两组患者均治疗1个疗程

疗程结束后统计疗效。比较两组患者治疗前后中医证候积分变化

急性生理功能和慢性健康状况评分Ⅱ(acute physiology and chronic health evaluationⅡ

APACHEⅡ)变化

血清降钙素原(PCT)、乳酸(Lac)含量变化

记录治疗期间两组患者的安全性情况。结果:经秩和检验

研究组患者的中医证候疗效分级情况优于对照组

研究组患者的总有效率为95.56%(43/45)

明显高于对照组的82.22%(37/45)

差异有统计学意义(P <0.05)。两组患者治疗后各项中医证候积分、APACHEⅡ评分明显低于治疗前

血清PCT、Lac含量明显低于治疗前

且研究组患者上述评分和血清指标含量明显低于对照组

差异均有统计学意义(P <0.05)。两组患者的治疗安全性均较好。结论:中药雾化吸入联合保留灌肠对多重耐药菌所致脓毒症(气分实热证)的疗效较好

可有效改善患者的临床症状和预后情况

降低患者血清PCT和Lac含量

且治疗安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of traditional Chinese medicine for aerosol inhalation combined with retention enema in the treatment of sepsis（ syndrome of excessive heat of qifen） caused by multidrugresistant organism（ MDRO）. METHODS: Totally 90 patients with sepsis（ syndrome of excessive heat of qifen） admitted into the ICU department of Jining Hospital of Traditional Chinese Medicine from Jun. 2019 to May 2020 were selected for prospective study

these patients were divided into research group and control group via random number table

with 45 cases in each group. Both groups had received standard treatment according to the "Guidelines for the Treatment of Severe Sepsis/Septic Shock in China"

the research group was given bluestone mixture for nebulized inhalation combined with modified Baihu decoction for retention enema

7 days were set as 1 course of treatment

both groups were treated for1 course

and the efficacy was counted at the end of treatment course. Changes of traditional Chinese medicine（ TCM）syndrome integral

acute physiology and chronic health evaluation Ⅱ（ APACHEⅡ） and serum procalcitonin（ PCT） and lactate（ Lac） contents were compared between two groups before and after treatment

the safety profile of the two groups was recorded. RESULTS: After rank-sum test

the TCM syndrome efficacy grading of patients in the research group was better than that of the control group

the total effective rate of patients in the research group was 95. 56%（ 43/45）

which was significantly higher than that of the control group（ 82. 22%

37/45）

with statistically significant difference（ P< 0. 05）. After treatment

the TCM syndrome integral and APACHEⅡ scores of both groups had been significantly decreased

the serum PCT and Lac levels were significantly lower than those of before treatment

and the above scores and serum index levels were significantly lower in the research group than those in the control group

with statistically significant differences（ P < 0. 05）. Both groups were in a good safety profile. CONCLUSIONS: The efficacy of traditional Chinese medicine for aerosol inhalation combined with retention enema in the treatment of sepsis（ syndrome of excessive heat of qifen） caused by MDRO is remarkable

which can effectively improve the clinical symptoms and prognosis of patients

reduce serum PCT and Lac levels

with good treatment safety.

关键词

脓毒症气分实热证中药雾化吸入保留灌肠

Keywords

SepsisSyndrome of excessive heat of qifenTraditional Chinese medicine for nebulized inhalationRetention enema

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