OBJECTIVE: To probe into the distribution of intestinal flora in overweight patients with type 2 diabetes mellitus and the intervention effect of liraglutide combined with metformin. METHODS: Totally 106 overweight patients with type 2 diabetes mellitus admitted into endocrinology department of the Second Affiliated Hospital of Xinjiang Medical University from Jul. 2019 to Jul. 2020 were extracted to be divided into the observation group and the control group via the random number table

with 53 cases in each group. Another 55 healthy physical examiners were selected as the healthy group. The number of intestinal flora of three groups was recorded. The control group was given metformin

while the observation group received liraglutide on the basis of control group. After treatment of 3 months

clinical efficacy

blood glucose

body mass index（ BMI）

visceral adipose tissue（ VAT） and adverse drug reactions in two groups were observed. RESULTS: Compared with the healthy group

the number of enterobacteriaceae bacteria and yeasts in the observation group and the control group was significantly higher

while the number of bifidobacterium and bacteroides were significantly lower

the differences were statistically significant（ P <0. 05）. However

there was no significant difference in the number of lactobacillus and enterococcus（ P > 0. 05）. The total effective rate of the observation group was 92. 45%（ 49/53）

significantly higher than that of the control group69. 81%（ 37/53）

with statistically significant difference（ P < 0. 05）. After treatment

the levels of fasting blood glucose

2 h postprandial blood glucose and Hb A1 c in the observation group were significantly lower than those in the control group

while BMI and VAT were significantly lower than those in the control group

the differences were statistically significant（ P < 0. 05）. The incidence of adverse drug reactions in the observation and control groups was13. 21%（ 7/53） and 11. 32%（ 6/53）

respectively

with no statistically significant difference（ P > 0. 05）.CONCLUSIONS: There is an imbalance of intestinal flora in overweight patients with type 2 diabetes mellitus

an increase in the number of enterobacteriaceae and yeasts

a decrease of bifidobacterium and bacteroides. Liraglutide combined with metformin is effective in the treatment of the disease

which is beneficial to improve the blood glucose levels without increasing adverse drug reactions.