OBJECTIVE: To probe into the administration regimen of caspofungin in children based on Monte Carlo simulation

so as to provide reference for individualized administration. METHODS: Pediatric patients were grouped according to age

combined with the distribution of the minimum inhibitory concentration（ MIC） of caspofungin against Candida and Aspergillus and the population pharmacokinetic parameters of caspofungin in pediatric patients

Crystal Ball11. 1. 2. 2 software was used to simulate different administration regimens of children in different age groups based on Monte Carlo model. The probability of targe attainment（ PTA） and cumulative fraction of response（ CFR） were used as evaluation indicators. RESULTS: The daily maintenance dose of caspofungin was 50 mg/m

2

and the maximum daily dose was 70 mg. In different age groups

for Candida infection

when the MIC value was ≤0. 06 μg/ml

the therapeutic effect could be satisfied. In this case

treatment of C. albicans

C. glabrata and C. tropicalis could meet CFR

>

90%

while CFR values for C. krusei ranged from 80% to 90% and

<

20% for C. glabrata. In contrast

for Aspergillus infection

MIC values ≤ 0. 015 μg/ml were required to meet the therapeutic effect

but none of the CFR values reached80%. CONCLUSIONS: Caspofungin had strong activity against C. albicans

C. glabrata and C. tropicalis

and its CFR value is related to the distribution of MIC. The combination of population pharmacokinetics and Monte Carlo model

and the implementation of individualized dosing regimens can ultimately achieve the desired therapeutic effect in individual children.