OBJECTIVE: To investigate the drugs taken orally within 3 months in the elderly with acute kidney injury（ AKI）

so as to provide evidence for clinical prevention of AKI in the elderly. METHODS: The clinical data

basic medical history and oral medication in recent 3 months of the elderly diagnosed with AKI who underwent renal needle biopsy in China-Japan Friendship Hospital from Jan.2001 to Jun.2020 were retrospectively analyzed.RESULTS:A total of 121 elderly patients with AKI met the inclusion criteria

including 65 male patients（ 53. 7%） and 56 female patients（ 46. 3%）.The median age was 65（ 62

69） years old.The pathological results of renal needle biopsy were acute interstitial nephritis in 37 cases（ 30. 6%） and subacute interstitial nephritis in 84 cases（ 69. 4%）. The median serum creatinine level was 216. 0（ 156. 5

323. 4） μmol/L at admission. After excluding the use of common nephrotoxic drugs such as non-steroid anti-inflammatory

antiviral drugs and antibiotics

the commonly used oral drugs were divided into antihypertensive drugs

hypoglycemic drugs

lipid-lowering drugs

diuretics

Chinese herbal medicines

anticoagulants or platelet aggregation inhibitors

uric acid-lowering drugs

gastrointestinal drugs and others（ methotrexate and epalrestat）. There were 103 cases（ 85. 1%） treated with antihypertensive drugs

44 cases（ 36. 4%） with hypoglycemic drugs

25 cases（ 20. 7%） with lipid-lowering drugs

25 cases（ 20. 7%） with diuretics

44 cases（ 36. 4%） with traditional Chinese medicine

20 cases（ 16. 5%） with anticoagulant or platelet aggregation inhibitors

9 cases（ 7. 4%） with uric acid-lowering drugs and 3 cases（ 2. 5%） with gastrointestinal drugs

and 34 cases（ 28. 1%） with other drugs.According to the number of types of drugs taken at the same time

there were21 cases（ 17. 4%） took one type of drug

49 cases（ 40. 5%） took two types of drugs

23 cases（ 19. 0%） took three types of drugs

19 cases（ 15. 7%） took four types of drugs

7 cases（ 5. 8%） took five types of drugs and 2 cases（ 1. 7%） took six types of drugs

the median of medication was 2（ 2

3）.CONCLUSIONS: The elderly are at high risk of drug-related AKI.Although they are taking common drugs

the drug combination of multiple common drugs has the risk of AKI.Therefore

during the medication period

attention should be paid to monitoring the changes in the patients’ renal function.