Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris

LI Xuejing; WANG Xianying; QIE Suhui; HAN Li

doi:10.14009/j.issn.1672-2124.2021.05.017

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Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris

更新时间：2022-10-08

- Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris
- Vol. 21, Issue 5, Pages: 584-589(2021)
- 作者机构：
  
  河北医科大学第三医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.05.017
  CLC： R259
- Published：2021，
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[1]李雪靖,王宪英,郄素会,韩丽.复方丹参滴丸与麝香保心丸分别治疗不稳定型心绞痛的药物经济学评价[J].中国医院用药评价与分析,2021,21(05):584-589.

LI Xuejing, WANG Xianying, QIE Suhui, et al. Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris. [J]. 21(5):584-589(2021)
[1]李雪靖,王宪英,郄素会,韩丽.复方丹参滴丸与麝香保心丸分别治疗不稳定型心绞痛的药物经济学评价[J].中国医院用药评价与分析,2021,21(05):584-589. DOI： 10.14009/j.issn.1672-2124.2021.05.017.

LI Xuejing, WANG Xianying, QIE Suhui, et al. Pharmacoeconomic Evaluation of Compound Danshen Dropping Pills and Shexiang Baoxin Pills in the Treatment of Unstable Angina Pectoris. [J]. 21(5):584-589(2021) DOI： 10.14009/j.issn.1672-2124.2021.05.017.

摘要

目的:综合评价复方丹参滴丸与麝香保心丸对比治疗不稳定型心绞痛（unstable angina pectoris

UAP）的临床效果和经济性。方法:全面检索中国知网、万方数据库、维普数据库和Pubmed等4个数据库

纳入在常规治疗基础上使用复方丹参滴丸或麝香保心丸治疗UAP的随机对照试验。通过贝叶斯网状Meta分析

比较两种药物的治疗效果

根据Meta分析结果选择成本-效果分析法或最小成本分析法来比较两者的经济性。结果:共纳入53篇文献

包含8 460例UAP患者。Meta分析结果显示

复方丹参滴丸与麝香保心丸治疗UAP的临床有效率比较

差异无统计学意义（RR=0.96

95%CI=0.87～1.07

P>0.05）。最小成本分析结果显示

复方丹参滴丸、麝香保心丸的治疗费用分别为121.7、191.5元;敏感性分析结果证明了该结果的稳健性。结论

在治疗UAP方面

复方丹参滴丸的经济性优于麝香保心丸。由于纳入研究质量一般

该结论有待大样本、高质量的临床随机对照试验进一步验证。

Abstract

OBJECTIVE: To comprehensively evaluate the clinical effect and economy of compound Danshen dropping pills and Shexiang baoxin pills in the treatment of unstable angina pectoris（ UAP）. METHODS: CNKI

Wanfang database

VIP database and PubMed were retrieved to collect the randomized controlled trial of compound Danshen dropping pills or Shexiang baoxin pills in the treatment of UAP on the basis of conventional treatment.Bayesian network Meta analysis was performed to compare the clinical effect of two regimens.According to the results of Meta analysis

cost-effectiveness analysis or minimum-cost analysis were selected to compare the economics of two regimens.RESULTS: A total of 53 literature were included

including 8 460 patients with UAP.Meta analysis showed that there was no statistically significant difference in the clinical effectiveness of compound Danshen dropping pills and Shexiang baoxin pills in the treatment of UAP（ RR = 0. 96

95% CI = 0. 87-1. 07

P > 0. 05）. Minimum cost analysis showed that the treatment cost of compound Danshen dropping pills and Shexiang baoxin pills were respectively121. 7 yuan and 191. 5 yuan.The results of sensitivity analysis proved the robustness of the results.CONCLUSIONS: In the treatment of UAP

compound Danshen dripping pills are more economical than Shexiang baoxin pills. Due to the general quality of the study

this conclusion needs to be further verified by large sample

high-quality randomized controlled clinical trials.

关键词

复方丹参滴丸麝香保心丸不稳定型心绞痛药物经济学评价

Keywords

Compound Danshen dropping pillsShexiang Baoxin pillsUnstable angina pectorisPharmacoeconomic evaluation

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