OBJECTIVE: To analyze the pharmacodynamic material basis and molecular mechanism of Kangfuyan capsules in the treatment of pelvic inflammatory disease（ PID） based on network pharmacology. METHODS: The corresponding chemical components and related drug and disease targets were collected through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（ TCMSP） and Bio-informatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine（ BATMAN-TCM） database

the interaction relationships between these targets were analyzed

the core target network was constructed

and the bioinformatics analysis of the core target was performed

and finally the herbal-component-target-pathway network of 11 kinds of ingredients of Kangfuyan capsules was established. RESULTS: Totally 249 kinds of components were screened out from Kangfuyan capsules

involving 460 key targets. The analysis on the former 150 core targets indicated that these core targets may participate in the treatment of PID by Kangwanyan capsules through influencing inflammatory signaling pathways including TNF signaling pathway

PI3 K-Akt signaling pathway

chemokine signaling pathway and T cell receptor signaling pathway

among which the four important inflammatory mediators of NOS1

CCL2

Sox9 and PTGS2 may be the important targets of Kangfuyan capsules in the treatment of PID. CONCLUSIONS: This study provides a theoretical basis for the treatment of PID with Kangfuyan capsules

an important reference for the next in vivo and ex vivo experiments as well as clinical studies.