Research on Drug Releasing Test of Meropenem Bone Cement in vitro

MAO Lu; WANG Xiaoxue; LIU Huifang; LIN Ping; ZHANG Bosong

doi:10.14009/j.issn.1672-2124.2021.05.013

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Research on Drug Releasing Test of Meropenem Bone Cement in vitro

更新时间：2022-10-08

- Research on Drug Releasing Test of Meropenem Bone Cement in vitro
- Vol. 21, Issue 5, Pages: 563-566(2021)
- 作者机构：
  
  1. 北京积水潭医院药学部
  2. 中日友好医院药学部
  3. 北京积水潭医院创伤骨科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.05.013
  CLC： R943
- Published：2021，
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[1]毛璐,王晓雪,刘慧芳,林平,张伯松.美罗培南骨水泥的体外释放研究[J].中国医院用药评价与分析,2021,21(05):563-566.

MAO Lu, WANG Xiaoxue, LIU Huifang, et al. Research on Drug Releasing Test of Meropenem Bone Cement in vitro. [J]. 21(5):563-566(2021)
[1]毛璐,王晓雪,刘慧芳,林平,张伯松.美罗培南骨水泥的体外释放研究[J].中国医院用药评价与分析,2021,21(05):563-566. DOI： 10.14009/j.issn.1672-2124.2021.05.013.

MAO Lu, WANG Xiaoxue, LIU Huifang, et al. Research on Drug Releasing Test of Meropenem Bone Cement in vitro. [J]. 21(5):563-566(2021) DOI： 10.14009/j.issn.1672-2124.2021.05.013.

摘要

目的:考察美罗培南骨水泥药柱的体外缓释规律

为临床使用提供参考。方法:用模具将美罗培南加入骨水泥中制成含美罗培南10%（W/W）的骨水泥植入剂

浸泡于37℃的改良模拟体液中

采用等距浸出法设定取样时间点

应用超高效液相色谱-串联质谱法对浸出液浓度进行检测

观察美罗培南骨水泥植入剂的释放规律。结果:美罗培南骨水泥药柱释药峰值出现在2 h

之后释药速率逐渐降低

19 h累计释放量达总体释放量的92.37%

在24 d内累积释放率达6.00%

体外释放曲线符合Weibull方程

r=0.915 1。结论:美罗培南骨水泥具有一定的缓释特性

释放主要集中在前72 h内

后期释放少。本研究结果可以为临床使用美罗培南治疗骨感染提供参考。

Abstract

OBJECTIVE: To investigate the release characteristic of meropenem bone cement in vitro

so as to provide reference for clinical application. METHODS: Meropenem was added into bone cement with a mould to make bone cement implant containing meropenem 10%（ W/W） and immersed in a modified simulated body fluid at 37 ℃ . The sampling time points were set by isometric leaching method

the concentration of leaching solution was measured by ultra performance liquid chromatography-tandem mass spectrometry to observe the release pattern of meropenem bone cement implant. RESULTS: The peak value of drug-release of meropenem bone cement grain occurred at 2 h

followed by gradual decrease of drug-releasing rate

and the cumulative releasing amount at 19 h had reached 92. 37% of the overall releasing amount

the cumulative releasing rate reached 6. 00% at 24 d. The in vitro release characteristic fitted the Weibull equation mold（ r = 0. 915 1）. CONCLUSIONS: The meropenem bone cement have delayed release characteristics

which mainly concentrates on the first 72 h

with little release in the later period. The result of this study can provide a reference for the clinical application of meropenem in the treatment of bone infections.

关键词

美罗培南骨水泥体外释放

Keywords

MeropenemBone cementIn vitro release

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