OBJECTIVE: To probe into the effects of periodontal basic treatment combined with heat-clearing and blood-cooling traditional Chinese medicine decoction on periodontal indexes

interleukin-1β（ IL-1β）

tumor necrosis factor α（ TNF-α） and matrix metalloproteinase-2（ MMP-2） levels in patients with dental implants. METHODS:Totally 76 patients with dentition defect admitted into Tangshan Union Hospital from Oct. 2018 to Apr. 2020 were extracted to be divided into the research group and the control group via the random number table

with38 cases in each group. Both groups received immediate restorative implant surgery. After surgery

the control group was given basic western medicine treatment

while the research group was treated with heat-clearing and blood-cooling traditional Chinese medicine decoction on the basis of the control group. Patients in both groups returned to the hospital for follow-up at 1 month after surgery. Before treatment and 1 month after treatment

the gingival sulcus bleeding index（ SBI）

gingival index（ GI）

plaque index（ PLI） and sulcus probing depth（ SPD） of two groups were detected by inspection and exploration. The levels of IL-1β

TNF-α and MMP-2 in gingival crevicular fluid of both groups were detected. RESULTS: Before treatment

there was no difference in SBI

GI

PLI and SPD between two groups（ P>0. 05）. After treatment

SBI

GI

PLI and SPD in the research group were significantly lower than those in the control group

with statistically significant difference（ P < 0. 05）. Before treatment

there was no significant difference in the levels of IL-1β

TNF-α and MMP-2 in gingival crevicular fluid between two groups（ P>0. 05）. After treatment

the levels of IL-1β

TNF-α and MMP-2 in the gingival crevicular fluid of the research group were significantly lower than those of the control group

and the differences were statistically significant（ P < 0. 05）.CONCLUSIONS: Periodontal basic treatment combined with heat-clearing and blood-cooling traditional Chinese medicine decoction can effectively improve the oral inflammation

promote the periodontal health

and reduce the levels of IL-1β

TNF-α

MMP-2 and other cytokines.