OBJECTIVE: To probe into the clinical effects of multi-drug combination application of preemptive analgesia in promoting rapid postoperative recovery of patients undergoing lower limb daytime operation in orthopedics.METHODS: Totally 150 patients undergoing lower limb daytime operation in orthopedics of Affiliated Hospital of Xiangnan University from Aug. 2018 to Jun. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 75 cases in each group. All patients were treated with intraspinal anesthesia and postoperative intravenous self-controlled analgesia. On this basis

the observation group received multidrug combination application of preemptive analgesia. Postoperative analgesia

sedation

vital indicators

incidence of postoperative nausea and vomiting（ PONV）

dosage of analgesics and postoperative length of stay were observed in both groups. RESULTS: The visual analogue scale（ VAS） score of the observation group was lower than that of the control group at 2

6

12 and 24 h after operation

the Ramsay score at 2 and 6 h after operation was higher than that of the control group

with statistically significant difference（ P < 0. 05）. There was no significant difference between two groups in the Ramsay score at 12 and 24 h after operation（ P > 0. 05）. There was no significant difference in systolic blood pressure（ SBP）

diastolic blood pressure（ DBP）

heart rate（ HR） and pulse oxygen saturation（ SpO2） between two groups at 2

6

12 and 24 h after operation（ P>0. 05）. The incidence of PONV in the observation group was 5. 33%（ 4/75）

significantly lower than 22. 67%（ 17/75） in the control group

and the difference was statistically significant（ P < 0. 05）. The dosage of analgesics tramadol at 24 h after operation in the observation group was less than that in the control group

the postoperative length of stay was shorter than that of the control group

with statistically significant difference（ P<0. 05）. CONCLUSIONS: Multi-Drug combination application of preemptive analgesia for patients undergoing lower limb daytime operation in orthopaedics can achieve good analgesic and sedative effects

reduce the incidence of PONV

decrease the dosage of analgesics and effectively promote the recovery process of patients after operation.