OBJECTIVE: To probe into the clinical efficacy of Zhizi Jinhua pills combined with Cydiodine buccal tablets in the treatment of recurrent oral ulcers（ ROU）. METHODS: Totally 102 patients with ROU admitted into Huai’an Stomatological Hospital from Jul. 2017 to Jun. 2019 were extracted to be divided into the control group and the research group via the random number table

with 51 cases in each group. The control group was treated with Cydiodine buccal tablets

while the research group received Zhizi Jinhua pills on the basis of the control group. Both groups were treated for 14 d. Clinical efficacy

adverse drug reactions

inflammatory factors and traditional Chinese medicine syndrome scores before and after treatment were observed in two groups. Recurrence was recorded at 6 months of follow-up. RESULTS: The disappearance time of burning pain and healing time of ulcer surface in the research group were shorter than those in the control group

with statistically significant difference（ P < 0. 05）. The total clinical efficiency in the research group was 92. 16%（ 47/51）

significantly higher than 76. 47%（ 39/51） in the control group

the difference was statistically significant（ P < 0. 05）. Compared with before treatment

the levels of interleukin-6（ IL-6）

high sensitive C-reactive protein（ hs-CRP）

tumor necrosis factor-α（ TNF-α） in two groups decreased significantly after treatment

and the research group was lower than the control group

with statistically significant difference（ P<0. 05）. After treatment

the scores of ulcer pain

burning sensation

ulcer exudation

ulcer area

ulcer hyperemia

thirst

edema and constipation decreased significantly in two groups

and the scores in the research group were lower than those in the control group

with statistically significant difference（ P<0. 05）. The recurrence rate of the research group was 9. 80%（ 5/51）

significantly lower than 27. 45%（ 14/51） in the control group

the difference was statistically significant（ P<0. 05）. The incidences of adverse drug reactions in the control group and the study group were respectively 3. 92%（ 2/51） and 5. 88%（ 3/51）

the difference was not statistically significant（ P > 0. 05）.CONCLUSIONS: The application of Zhizi Jinhua pills combined with Cydiodine buccal tablets in the treatment of recurrent oral ulcer can rapidly improve the clinical symptoms of patients

effectively control the conditions

reduce the levels of inflammatory factors and the recurrence of ulcer

which has higher clinical application value.