Homocysteine is an intermediate metabolite in the metabolic pathway of methionine. Over the years

researches have proved that hyperhomocysteinemia is related to the occurrence of diseases such as hypertension

stroke

depression

Alzheimer’s disease

diabetic peripheral neuropathy and chronic kidney disease. Although folic acid can effectively reduce the level of homocysteine in the body

it may have off-label indications

overdose and other irrational phenomena in the treatment of diseases related to hyperhomocysteine. It is suggested that standard dosage and individualized administration of folic acid should be adopted in clinical application.