OBJECTIVE: To investigate the medication rules and clinical application of traditional Chinese medicine preparations containing ephedra in Beijing Hospital of Traditional Chinese Medicine

Capital Medical University（ hereinafter referred to as "our hospital"）

so as to provide reference for improving the level of clinical rational drug application and ensuring the medication safety for patients. METHODS: Traditional Chinese Medicine Inheritance Assist Platform（ 2. 5） was used to analyze the medication rules of traditional Chinese medicine preparations containing ephedra in our hospital

and the ephedrine content of each preparation was quantified. Taking Zhisou Huatan Dingchuan pills as an example

2 170 outpatient prescriptions containing Zhisou Huatan Dingchuan Pills were retrieved through the hospital HIS system in Apr. 2019

and the clinical application of Zhisou Huatan Dingchuan pills was analyzed. RESULTS: In our hospital

there were 16 kinds of traditional Chinese medicine preparations containing ephedra

including 85 varieties

mainly for heat-clearing and phlegm-reducing

cough relieving and antiasthmatic drugs. The main diseases were cough and cold

and the most common symptoms were wind-heat syndromes. Zhisou Huatan Dingchuan pills were mostly used in respiratory department

pediatrics department and cardiovascular department in clinic. The commonly used core drug combinations in the prescription of Zhisou Huatan Dingchuan pills were traditional Chinese medicine preparations containing ephedra

such as Qingfei pills

Suhuang Zhike capsules

Jinhua Qinggan granules and Sanao tablets. There were a variety of traditional Chinese medicine preparations containing ephedrine combined with Zhisou Huatan Dingchuan pills

and there were also irrational drug combination of Zhisou Huatan Dingchuan pills and Western medicine

mainly including antihypertensive drugs. Some special patients

such as hypertension

heart disease

insomnia and other patients also received a variety of traditional Chinese medicine preparations containing ephedra at the same time

and the risk of medication increased greatly.CONCLUSIONS: It is of great significance to strengthen the supervision of the safe medication of traditional Chinese medicine preparations containing ephedra

to systematically quantify the ephedrine content in various preparations containing ephedra

and to standardize the application of traditional Chinese medicine preparations containing ephedra or to formulate corresponding standards for themedication in clinic.