OBJECTIVE: To systematically evaluate the efficacy and safety of lopinavir/ritonavir in the treatment of patients with COVID-19. METHODS: PubMed

CNKI

Wanfang datebase and VIP database were retrieved to collect the randomized controlled trial of lopinavir/ritonavir in the treatment of patients with COVID-19（ the lopinavir/ritonavir group was treated with lopinavir/ritonavir combined with conventional treatment

while the control group received conventional treatment）

the retrieval time was from the establishment of the database to Aug. 21 st

2020. According to Cochrane 5. 3 criteria

the included literature were evaluated for the risk of bias. According to the non-random bias risk assessment method recommended by the Cochrane Collaboration Newcastle-Ottawa scale（ NOS）

the quality of the included literature was averaged. RevMan 5. 3 software was used for Meta-analysis. RESULTS: A total of 7 literature were included

including 846 patients with COVID-19. Meta-analysis showed that there was no statistically significant difference in duration of fever between two groups（ SMD =-0. 18

95% CI =-0. 66-0. 31

P = 0. 48

I

2

= 72%）.Compared with the conventional treatment

lopinavir/ritonavir regimen was more effective in shortening the disease course of COVID-19 patients（ SMD =-0. 17

95% CI =-0. 33--0. 01

P = 0. 03

I

2

= 10%）

and had significant advantages in negative time of severe acute respiratory syndrome coronavirus 2（ SARS-CoV-2） nucleic acid detection（ SMD =-0. 79

95% CI =-1. 42--0. 17

P = 0. 01

I

2

= 91%）

yet had higher incidence of adverse drug reactions（ OR = 3. 15

95% CI = 1. 37-7. 21

P = 0. 007

I

2

= 72%）

the differences were statistically significant. There was no significant difference in mortality between two groups（ OR = 0. 78

95% CI = 0. 43-1. 41

P = 0. 41

I

2

= 0%）.CONCLUSIONS: Lopinavir/ritonavir can effectively shorten the disease course of COVID-19 patients and the negative time of SARS-CoV-2 nucleic acid detection

but the improvement effect on clinical symptoms is not significant

and it is necessary to pay close attention to the safety in clinic.