Systematic Review of Efficacy and Safety of Xingnaojing Injection Combined with Shuxuetong Injection in the Treatment of Cerebral Infarction

PENG Jiabing; YAN Anding; FAN Zongbing; ZHANG Feng; WANG Longsheng; SUN Kai

doi:10.14009/j.issn.1672-2124.2021.04.020

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Systematic Review of Efficacy and Safety of Xingnaojing Injection Combined with Shuxuetong Injection in the Treatment of Cerebral Infarction

更新时间：2022-10-08

- Systematic Review of Efficacy and Safety of Xingnaojing Injection Combined with Shuxuetong Injection in the Treatment of Cerebral Infarction
- Vol. 21, Issue 4, Pages: 469-472(2021)
- 作者机构：
  
  安徽医科大学附属阜阳医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.04.020
  CLC： R277.7
- Published：2021，
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[1]彭加兵,严安定,樊宗兵,张凤,汪龙生,孙凯.醒脑静注射液联合疏血通注射液治疗脑梗死的有效性和安全性的系统评价[J].中国医院用药评价与分析,2021,21(04):469-472+477.

PENG Jiabing, YAN Anding, FAN Zongbing, et al. Systematic Review of Efficacy and Safety of Xingnaojing Injection Combined with Shuxuetong Injection in the Treatment of Cerebral Infarction. [J]. 21(4):469-472(2021)
[1]彭加兵,严安定,樊宗兵,张凤,汪龙生,孙凯.醒脑静注射液联合疏血通注射液治疗脑梗死的有效性和安全性的系统评价[J].中国医院用药评价与分析,2021,21(04):469-472+477. DOI： 10.14009/j.issn.1672-2124.2021.04.020.

PENG Jiabing, YAN Anding, FAN Zongbing, et al. Systematic Review of Efficacy and Safety of Xingnaojing Injection Combined with Shuxuetong Injection in the Treatment of Cerebral Infarction. [J]. 21(4):469-472(2021) DOI： 10.14009/j.issn.1672-2124.2021.04.020.

摘要

目的:系统评价醒脑静注射液联合疏血通注射液治疗脑梗死的有效性和安全性。方法:计算机检索Pub Med、the Cochrane Library、Web of Science、EMBase、中国生物医学网、维普数据库、中国知网和万方数据库

检索时限均为建库至2020年10月

查找有关醒脑静注射液联合疏血通注射液治疗脑梗死的随机对照研究文献（研究组患者采用醒脑静注射液联合疏血通注射液治疗

对照组患者采用常规方案、疏血通注射液、疏血通注射液联合小牛血或七叶皂苷钠联合胞二磷胆碱治疗）

对纳入的文献进行质量评价和资料提取后

采用Rev Man 5.3统计软件进行荟萃分析（Meta分析）。结果:共纳入9篇文献

均为随机对照试验

合计706例患者。Meta分析结果显示

研究组患者的总有效率（OR=3.96

P <0.000 01）、治愈率（OR=2.20

P <0.000 01）均明显优于对照组

死亡率（OR=0.28

P=0.03）、神经功能缺损评分（MD=-4.45

P <0.000 01）均明显低于对照组

差异均有统计学意义;两组患者不良反应发生率的差异无统计学意义（P=0.24）。结论:醒脑静注射液联合疏血通注射液治疗脑梗死的疗效优于对照方案（常规方案、疏血通注射液、疏血通注射液联合小牛血或七叶皂苷钠联合胞二磷胆碱治疗）

在安全性方面两者相当。但由于纳入的研究质量较低

样本量较小

因此上述结果仍需要大规模、多中心的临床随机对照试验进一步证实。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of Xingnaojing injection combined with Shuxuetong injection in the treatment of cerebral infarction. METHODS: PubMed

the Cochrane Library

Web of Science

EMBase

CBM

VIP database

CNKI and Wanfang database were retrieved to collect the randomized controlled trial of Xingnaojing injection combined with Shuxuetong injection in the treatment of cerebral infarction（ the study group was treated with Xingnaojing injection combined with Shuxuetong injection

while the control group received conventional regimen

Shuxuetong injection

Shuxuetong injection combined with calf blood or sodium aescinate combined with citicoline treatment）

the retrieval time was from the establishment of the database to Oct.2020. After the quality assessment and data extraction of included literature

RevMan 5. 3 statistical software was used for Meta-analysis. RESULTS: A total of 9 literature were included

all of which were randomized controlled trials

with a total of 706 patients. Meta-analysis showed that the total effective rate（ OR = 3. 96

P < 0. 000 01） and cure rate（ OR= 2. 20

P < 0. 000 01） in the study group were significantly better than those in the control group

and the mortality rate（ OR = 0. 28

P = 0. 03） and neurological deficit scores（ MD =-4. 45

P < 0. 000 01） in the study group were significantly lower than those in the control group

with statistically significant differences. There was no statistically significant difference in the incidence of adverse drug reactions between two groups（ P = 0. 24）. CONCLUSIONS: The efficacy of Xingnaojing injection combined with Shuxuetong injection in the treatment of cerebral infarction is better than that of the control regimens（ conventional regimen

Shuxuetong injection

Shuxuetong injection combined with calf blood or sodium aescinate combined with citicoline treatment）

the two are equivalent in terms of safety. However

due to the lower quality of included literature and the small sample size

the results still need to be further confirmed by large-scale

multi-center clinical randomized controlled trials.

关键词

醒脑静注射液疏血通注射液脑梗死Meta分析

Keywords

Xingnaojing injectionShuxuetong injectionCerebral infarctionMeta-analysis

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