Mechanism of Semen Cuscutae Pills of Lingzhu in the Treatment of Renal Proteinuria Based on Network Pharmacology

TAO Jie; XU Chuanlan; MING Yao; ZHAO Sha; SHEN Hongchun

doi:10.14009/j.issn.1672-2124.2021.04.015

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Mechanism of Semen Cuscutae Pills of Lingzhu in the Treatment of Renal Proteinuria Based on Network Pharmacology

更新时间：2022-10-08

- Mechanism of Semen Cuscutae Pills of Lingzhu in the Treatment of Renal Proteinuria Based on Network Pharmacology
- Vol. 21, Issue 4, Pages: 444-450(2021)
- 作者机构：
  
  1. 西南医科大学中西医结合学院
  2. 西南医科大学中西医结合学院中医诊断学教研室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.04.015
  CLC： R285
- Published：2021，
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[1]陶杰,徐川岚,明瑶,赵莎,沈宏春.基于网络药理学探讨苓术菟丝子丸治疗肾性蛋白尿的作用机制[J].中国医院用药评价与分析,2021,21(04):444-450.

TAO Jie, XU Chuanlan, MING Yao, et al. Mechanism of Semen Cuscutae Pills of Lingzhu in the Treatment of Renal Proteinuria Based on Network Pharmacology. [J]. 21(4):444-450(2021)
[1]陶杰,徐川岚,明瑶,赵莎,沈宏春.基于网络药理学探讨苓术菟丝子丸治疗肾性蛋白尿的作用机制[J].中国医院用药评价与分析,2021,21(04):444-450. DOI： 10.14009/j.issn.1672-2124.2021.04.015.

TAO Jie, XU Chuanlan, MING Yao, et al. Mechanism of Semen Cuscutae Pills of Lingzhu in the Treatment of Renal Proteinuria Based on Network Pharmacology. [J]. 21(4):444-450(2021) DOI： 10.14009/j.issn.1672-2124.2021.04.015.

摘要

目的:运用网络药理学方法

初步探讨苓术菟丝子丸治疗肾性蛋白尿的作用机制。方法:通过中药系统药理学数据库与分析平台获取苓术菟丝子丸组方药物的活性成分及其靶点

利用人类孟德尔遗传综合数据库、Gene Cards数据库获取肾性蛋白尿的靶点

将获得的数据集进行Venn分析得到苓术菟丝子丸作用于肾性蛋白尿的靶点。通过String数据库构建蛋白互作网络

并在Cytoscape软件中进行可视化处理。利用DAVID数据库进行基因本体（gene ontology

GO）功能富集分析及京都基因与基因组百科全书（Kyoto encyclopedia of genes and genomes

KEGG）通路富集分析。结果:苓术菟丝子丸作用于肾性蛋白尿的活性成分有138个

共同作用的靶点有75个。GO功能富集分析共查询到93个条目; KEGG通路富集分析共查询到119个条目

其中包括肿瘤信号通路、细胞凋亡过程、肿瘤坏死因子信号通路等。结论:本研究通过网络药理学预测了苓术菟丝子丸治疗肾性蛋白尿的作用机制

可为进一步的研究提供参考。

Abstract

OBJECTIVE: To preliminarily investigate the mechanism of Semen cuscutae pills of Lingzhu in the treatment of renal proteinuria based on network pharmacology. METHODS: TCMSP was used for getting the active ingredients and targets of components of Semen cuscutae pills of Lingzhu

the targets related with renal proteinuria were obtained by searching OMIM and Gene Cards databases

Venn analysis of the obtained data sets was carried out to acquire the target of Semen cuscutae pills of Lingzhu on renal proteinuria. Visualized processing was conducted by Cytoscape software after the construction of protein interaction network by String database. Gene ontology（ GO） function enrichment analysis and Kyoto encyclopedia of genes and genomes（ KEGG） pathway enrichment analysis were carried out based on DAVID database. RESULTS: There were 138 kinds of active ingredient and 75 concurrent targets of Semen cuscutae pills of Lingzhu acting on renal proteinuria. 93 items was inquired from GO function enrichment analysis;119 items were inquired from KEGG function enrichment analysis

including tumor signal pathway

process of cell apoptosis

tumor necrosis factor signal pathway

etc. CONCLUSIONS: The mechanism of Semen cuscutae pills of Lingzhu in the treatment of renal proteinuria has been predicted through network pharmacology

which could provide reference for further study.

关键词

苓术菟丝子丸肾性蛋白尿网络药理学作用机制

Keywords

Semen cuscutae pills of LingzhuRenal proteinuriaNetwork pharmacologyMechanism

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