OBJECTIVE: To probe into the treatment effects of self-made Tongqiao Dingxuan decoction combined with Betahistine mesylate tablets in the treatment of posterior circulation ischemic vertigo with phlegm stasis obstruction. METHODS: Totally 96 patients with posterior circulation ischemic vertigo with phlegm stasis obstruction admitted into West China Hospital

Sichuan University from 2017 to 2019 were extracted to be divided into the control group and the study group via the random number table

with 48 cases in each group. The control group was treated with Betahistine mesylate tablets

while the study group received self-made Tongqiao Dingxuan decoction on the basis of the control group. Two groups were treated for 14 d. The differences in clinical efficacy

traditional Chinese medicine syndrome score and improvement of hemorheology indicators between two groups were compared

and the incidence of adverse drug reactions was recorded. RESULTS: The total clinical effective rate of the study group was93. 75%（ 45/48）

significantly higher than the control group 68. 75%（ 33/48）

the difference was statistically significant（ P < 0. 05）. After one course of treatment

symptom scores of vertigo

nausea and vomiting

fatigue

tinnitus and deafness and clouded heavy head

plasma viscosity

whole blood viscosity and fibrinogen level in both groups were significantly lower than those before treatment

and the study group was lower than the control group

with statistically significant difference（ P < 0. 05）. The mean blood flow velocity of vertebral artery and basilar artery in two groups were significantly higher than those before treatment

and the study group was higher than the control group

with statistically significant difference（ P < 0. 05）. The incidence of adverse drug reactions in control group and study group was respectively 8. 33%（ 4/48） and 12. 50%（ 6/48）

there was no significant difference between two groups（ P > 0. 05）. CONCLUSIONS: The efficacy of self-made Tongqiao Dingxuan decoction combined with Betahistine mesylate tablets in the treatment of posterior circulation ischemic vertigo with phlegm stasis obstruction is significant

which can improve the clinical symptoms and hemorheology indicators with higher safety.