OBJECTIVE: To explore the effect of Zishen Yutai pills on the level of soluble human leukocyte antigen G（ s HLA-G） and anti-endometrial antibody（ Em Ab） in patients with recurrent abortion with positive anticardiolipin antibody（ ACA）. METHODS: Totally 102 patients with recurrent abortion with positive ACA admitted into Hebei General Hospital from Aug. 2017 to Oct. 2020 were extracted to be divided into the control group and Zishen Yutai pills group via the stratified sampling method

with 51 cases in each group. The control group was treated with conventional treatment

while the Zishen Yutai pills group received Zishen Yutai pills. Enzyme-Linked immunosorbent assay（ ELISA）was used to detect tumor necrosis factor-related protein 12（ CTRP12）

s HLA-G

anti-Mullerian hormone（ AMH）

prostaglandin E2（ PGE2）

cyclooxygenase 2（ COX-2）

β-human chorionic gonadotropin（ β-HCG）

anti-sperm antibody（ As Ab）

Emab and ACA. The levels of progesterone（ P）

luteinizing hormone（ LH） and testosterone（ T）were measured by automatic biochemical analyzer

and the clinical efficacy of two groups was observed. RESULTS:Compared with the control group

the levels of CTRP12 and s HLA-G in the Zishen Yutai pills group increased significantly

and the levels of AMH decreased significantly after treatment

and the differences were statistically significant（ P < 0. 05）. Compared with the control group

the level of P increased significantly

and the levels of T and LH decreased significantly in the Zishen Yutai pills group after treatment

with statistically significant difference（ P <0. 05）. Compared with the control group

the levels of PGE2

COX-2 and β-HCG in the Zishen Yutai pills group increased significantly after treatment

with statistically significant difference（ P < 0. 05）. Compared with the control group

the positive rates of Em Ab

ACA and As Ab in the Zishen Yutai pills group decreased significantly after treatment

and the difference was statistically significant（ P < 0. 05）. The total effective rate of Zishen Yutai pills group was 94. 12%（ 48/51）

compared with 78. 43%（ 40/51） of the control group

the difference was statistically significant（ P <0. 05）. CONCLUSIONS: Zishen Yutai pills in the treatment of positive ACA can increase the level of s HLA-G

decrease the positive rate of Em Ab and improve the sex hormone of patients with significant efficacy.