OBJECTIVE: To probe into the efficacy of calculus bovis cultured in vitro in the adjuvant treatment of nasopharyngeal carcinoma complicated with pulmonary infection. METHODS: A total of 180 patients with nasopharyngeal carcinoma complicated with pulmonary infection admitted into Chongqing University Cancer Hospital from Feb. 2018 to Oct. 2020 were extracted to be divided into the study group and the control group

with 90 cases in each group. Both groups were treated with piperacillin sodium and tazobactam sodium for injection via the random number table

while the study group received bovis cultured in vitro. Clinical efficacy

disappearance time of cough and fever

application time of antibiotics

immune function indicators and occurrence of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of the study group was 85. 56%（ 77/90）

significantly higher than that of the control group 56. 67%（ 51/90）

the difference was statistically significant（ P

<

0. 05）. The disappearance time of cough and fever

application time of antibiotics in the study group were shorter than those in the control group

with statistically significant difference（ P

<

0. 01）. After treatment

the immune function indicators such as CD4

+

and CD4

+

/CD8

+

of the study group were significantly higher than those of the control group

and CD8

+

was significantly lower than that of the control group

and the differences were statistically significant（ P

<

0. 05）. The incidence of nausea in the study group was significantly lower than that in the control group

and the difference was statistically significant（ P

<

0. 05）. There was no significant difference in the incidence of elevated serum aminotransferase

diarrhea and skin rash between two groups（ P

>

0. 05）. CONCLUSIONS: The efficacy of calculus bovis cultured in vitro in the adjuvant treatment of nasopharyngeal carcinoma complicated with pulmonary infection is significant

which is better than piperacillin sodium and tazobactam sodium for injection alone.