Efficacy of Intravenous Chemotherapy Combined with Radiotherapy in the Treatment of Recurrence of Ipsilateral Supraclavicular Lymph Nodes Metastasis of Breast Cancer

MA Nina; ZHAO Hong; LIN Haishan; CAO Bangwei

doi:10.14009/j.issn.1672-2124.2021.04.005

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Efficacy of Intravenous Chemotherapy Combined with Radiotherapy in the Treatment of Recurrence of Ipsilateral Supraclavicular Lymph Nodes Metastasis of Breast Cancer

更新时间：2022-10-08

- Efficacy of Intravenous Chemotherapy Combined with Radiotherapy in the Treatment of Recurrence of Ipsilateral Supraclavicular Lymph Nodes Metastasis of Breast Cancer
- Vol. 21, Issue 4, Pages: 405-408(2021)
- 作者机构：
  
  首都医科大学附属北京友谊医院肿瘤中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.04.005
  CLC： R737.9
- Published：2021，
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[1]马妮娜,赵宏,林海珊,曹邦伟.静脉化疗联合放疗对乳腺癌同侧锁骨上淋巴结转移复发的疗效研究[J].中国医院用药评价与分析,2021,21(04):405-408.

MA Nina, ZHAO Hong, LIN Haishan, et al. Efficacy of Intravenous Chemotherapy Combined with Radiotherapy in the Treatment of Recurrence of Ipsilateral Supraclavicular Lymph Nodes Metastasis of Breast Cancer. [J]. 21(4):405-408(2021)
[1]马妮娜,赵宏,林海珊,曹邦伟.静脉化疗联合放疗对乳腺癌同侧锁骨上淋巴结转移复发的疗效研究[J].中国医院用药评价与分析,2021,21(04):405-408. DOI： 10.14009/j.issn.1672-2124.2021.04.005.

MA Nina, ZHAO Hong, LIN Haishan, et al. Efficacy of Intravenous Chemotherapy Combined with Radiotherapy in the Treatment of Recurrence of Ipsilateral Supraclavicular Lymph Nodes Metastasis of Breast Cancer. [J]. 21(4):405-408(2021) DOI： 10.14009/j.issn.1672-2124.2021.04.005.

摘要

目的:探讨静脉化疗联合放疗在复发的同侧锁骨上淋巴结转移（ipsilateral supraclavicular lymph node metastasis

ISLM）而无远处转移的乳腺癌患者中的作用。方法:回顾性选取2008年7月至2019年7月首都医科大学附属北京友谊医院收治的61例女性复发的ISLM乳腺癌患者的病历资料。所有患者均采用含蒽环类或紫杉类药物的方案化疗6～8个周期和治愈性放疗。在第3次与第4次化疗的间隔进行放疗

雌激素受体、孕激素受体或人类表皮生长因子受体2阳性患者分别采用内分泌或靶向治疗。采用Kaplan-Meier法计算总生存期（OS）、无病生存期（DFS）

采用Log-rank法检验差异。结果:化疗、放疗后患者的临床总缓解率为94%（51/54）

中位无进展生存时间和OS分别为31和45个月

5年总生存率和无病生存率为38%和22%。结论:对于复发的ISLM乳腺癌患者

静脉化疗联合局部放疗是一个优化的选择。

Abstract

OBJECTIVE: To probe into the effect of intravenous chemotherapy combined with radiotherapy in breast cancer patients with recurrence of ipsilateral supraclavicular lymph node metastasis（ ISLM） without distant metastasis. METHODS: Case data of 61 female patients with recurrence of ISLM of breast cancer admitted into Beijing Friendship Hospital Affiliated to Capital Medical University from Jul. 2008 to Jul. 2019 were retrospectively selected.All the patients were given chemotherapy with antharcyclines or taxanes drugs for 6 to 8 cycles and healing radiotherapy. Radiotherapy was performed between the 3 rd and 4 th chemotherapy

patients with positive estrogen receptor

progesterone receptor or human epidermal growth factor receptor 2 were respectively given endocrine therapy or targeted therapy. Overall survival（ OS） and disease free survival（ DFS） were calculated by Kaplan-Meier method

and differences were inspected by Log-rank method. RESULTS: The clinical total remission rate of patients after radiotherapy and chemotherapy were 94%（ 51/54）

the median progression-free survival and OS were respectively 31 and 45 months

the total survival rate in 5 years and DFS were respectively 38% and 22%. CONCLUSIONS: For the patients with recurrence of ISLM of breast cancer

intravenous chemotherapy combined with local radiotherapy is an optimizing choice.

关键词

静脉化疗放疗乳腺癌淋巴结转移

Keywords

Intravenous chemotherapyRadiotherapyBreast cancerLymph node metastasis

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