Analysis on Rationality and Research on Drug Utilization of Lienal Polypeptide Injection in 296 Children

AN Na; ZHANG Guying; JIA Chenhong; DING Xiangyu; LIU Yanhui; LI Ruihong; LIANG Yuli

doi:10.14009/j.issn.1672-2124.2021.03.023

您当前的位置：

首页 >

文章列表页 >

Analysis on Rationality and Research on Drug Utilization of Lienal Polypeptide Injection in 296 Children

更新时间：2022-10-08

- Analysis on Rationality and Research on Drug Utilization of Lienal Polypeptide Injection in 296 Children
- Vol. 21, Issue 3, Pages: 358-361(2021)
- 作者机构：
  
  1. 河北省儿童医院药学部
  2. 河北省儿童医院血液科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.03.023
  CLC： R969.3
- Published：2021，
扫描看全文
[1]安娜,张古英,贾晨虹,丁翔宇,刘艳辉,李瑞宏,梁玉丽.296例儿童患者脾多肽注射液应用合理性分析及药物利用研究[J].中国医院用药评价与分析,2021,21(03):358-361+365.

AN Na, ZHANG Guying, JIA Chenhong, et al. Analysis on Rationality and Research on Drug Utilization of Lienal Polypeptide Injection in 296 Children. [J]. 21(3):358-361(2021)
[1]安娜,张古英,贾晨虹,丁翔宇,刘艳辉,李瑞宏,梁玉丽.296例儿童患者脾多肽注射液应用合理性分析及药物利用研究[J].中国医院用药评价与分析,2021,21(03):358-361+365. DOI： 10.14009/j.issn.1672-2124.2021.03.023.

AN Na, ZHANG Guying, JIA Chenhong, et al. Analysis on Rationality and Research on Drug Utilization of Lienal Polypeptide Injection in 296 Children. [J]. 21(3):358-361(2021) DOI： 10.14009/j.issn.1672-2124.2021.03.023.

摘要

目的:探讨脾多肽注射液在儿童患者中的应用合理性及药物利用研究。方法:随机抽取2018年6月至2019年5月某儿童医院296例使用脾多肽注射液患儿的病历资料

结合药品说明书、《处方管理办法》、《儿童临床使用免疫调节剂专家共识》以及患儿年龄、体重

建立儿童脾多肽注射液临床合理应用评分标准

包括适应证、药物剂量、溶剂种类、药物浓度、给药频次、联合用药和免疫功能检查等7项指标

对各项指标进行合理性评价

合理记1分

计算各指标合理率及总得分百分率

初步探讨脾多肽注射液在儿童患者中的合理用药评价方法。结果:用药评价结果显示

得分率由高至低依次为药物剂量（100%

296例）、溶剂种类（100%

296例）、给药频次（100%

296例）、适应证（97.97%

290例）、联合用药（95.61%

283例）、药物浓度（79.73%

236例）、免疫功能检查（61.82%

183例）。对患儿的体重进行分组分析

结果显示

单位体质量用药量与体重呈负相关。药物利用分析结果显示

儿童剂量药物利用指数（dose of children drug utilization index

d CDUI）随着体重的增加而降低

且低体重患儿的d CDUI>1

存在过度应用现象;高体重患儿的d CDUI<1

存在用药不足问题。不同体重分组患儿的儿童浓度药物利用指数（concentration of children drug utilization index

c CDUI）均>1

超浓度应用现象严重。结论:应规范脾多肽注射液在儿童患者中的临床应用

促进合理用药。

Abstract

OBJECTIVE: To probe into the application rationality and drug utilization of lienal polypeptide injection in children.METHODS: Medical history of 296 children treated with lienal polypeptide injection in a certain children’s hospital from Jun.2018 to May 2019 were randomly extracted

combining with the drug instructions

the"Prescription Management Measures"

the"Expert Consensus on Clinical Use of Immunomodulators in Children"and the age and weight of children

a scoring standard for the clinical rational application of lienal polypeptide injection on children was established

including 7 indicators of indications

drug dosage

solvent type

drug concentration

administration frequency

drug combination and immune function examination

the rationality of each indicator was evaluated

and 1 point scored when rational

the rational rate and total points were calculated

so as to preliminarily discuss the evaluation method of rational application of lienal polypeptide injection in children.RESULTS: Results of medication evaluation showed that the scoring rates from high to low were respectively drug dosage（ 100%

296 cases）

solvent type（ 100%

296 cases）

administration frequency（ 100%

296 case）

drug indications（ 97.97%

290 cases）

drug combination（ 95.61%

283 cases）

drug concentration（ 79.73%

236 cases）

immune function examination（ 61.82%

183 cases）.Results of analysis on children’s weight showed that the amount of medicine used per unit body weight was negatively correlated with body weight.Results of drug utilization analysis showed that the dose of children drug utilization index（ dCDUI） decreased with the increase of weight

and the d CDUI of children with low birth weight was >1

there was excessive application; the d CDUI of children with high body weight was <1

there was insufficient application.All the concentration of children drug utilization index（ cCDUI） of children in different weight groups was >1

there was over-concentration application.CONCLUSIONS: The application of lienal polypeptide injection in children should be standardized to promote rational drug application.

关键词

脾多肽注射液儿童剂量儿童药物利用指数合理用药

Keywords

Lienal polypeptide injectionChild doseChildren drug utilization indexRational drug application

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application Rationality of Traditional Chinese Medicine Injections in Our Hospital from the Perspective of Adjuvant Drug Management

Key Points and Reflections of Rational Clinical Application of Anti-Tumor Traditional Chinese Medicine Injection

Application Rationality of Probiotics in Children with Inflammatory Bowel Disease in Two Children’s Hospitals of Beijing

An Annual Effect Analysis on the First Batch of Pilot Project of National-Organized Centralized Drug Procurement and Application in A Certain Grade Ⅲ Level A General Hospital in Chongqing

Analysis of Clinical Application and Management Mode of Antibiotics in A Grade Ⅲ,Level A Hospital in Ningxia

Related Author

SUN Shijiang

CHENG Jie

CHEN Pinying

FAN Shunxin

SHI Jing

GAO Xu

MA Juanjuan

LI Lianying

Related Institution

Dept.of Pharmacy, Traditional Chinese Medicine Hospital of Hebei Luanping County

Dept.of Pharmacy, Hebei Provincial Hospital of Traditional Chinese Medicine, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation

Dept.of Medical Oncology, Guang’anmen Hospital of China Academy of Chinese Medical Sciences

Dept.of Pharmacy, Guang’anmen Hospital of China Academy of Chinese Medical Sciences

Clinical Research Center,Beijing Children’s Hospital,Capital Medical University

⁰