Systematic Review of Efficacy of Milinone in the Treatment of Persistent Pulmonary Hypertension of the Newborn

LI Haizhi; WANG Dan; LI Te

doi:10.14009/j.issn.1672-2124.2021.03.016

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Systematic Review of Efficacy of Milinone in the Treatment of Persistent Pulmonary Hypertension of the Newborn

更新时间：2022-10-08

- Systematic Review of Efficacy of Milinone in the Treatment of Persistent Pulmonary Hypertension of the Newborn
- Vol. 21, Issue 3, Pages: 324-328(2021)
- 作者机构：
  
  1. 云南省阜外心血管病医院药剂科
  2. 云南经济管理学院医学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.03.016
  CLC： R722.1
- Published：2021，
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[1]李海志,王丹,李特.米力农治疗新生儿持续性肺动脉高压有效性的系统评价[J].中国医院用药评价与分析,2021,21(03):324-328.

LI Haizhi, WANG Dan, LI Te. Systematic Review of Efficacy of Milinone in the Treatment of Persistent Pulmonary Hypertension of the Newborn. [J]. 21(3):324-328(2021)
[1]李海志,王丹,李特.米力农治疗新生儿持续性肺动脉高压有效性的系统评价[J].中国医院用药评价与分析,2021,21(03):324-328. DOI： 10.14009/j.issn.1672-2124.2021.03.016.

LI Haizhi, WANG Dan, LI Te. Systematic Review of Efficacy of Milinone in the Treatment of Persistent Pulmonary Hypertension of the Newborn. [J]. 21(3):324-328(2021) DOI： 10.14009/j.issn.1672-2124.2021.03.016.

摘要

目的:系统评价抗心力衰竭药米力农在临床上新的药物治疗作用

即用于新生儿持续性肺动脉高压（persistent pulmonary hypertension of the newborn

PPHN）的有效性

为循证医学提供用药参考及新的治疗方法。方法:计算机检索PubMed、EMBase、Medline、Cochrane图书馆、中国知网、维普中文期刊数据库、万方数字化期刊全文数据库和中国生物医学文献数据库

检索时限为各数据库建库起至2019年10月

收集使用米力农+常规治疗（研究组）对比常规治疗（对照组）用于PPHN的随机对照试验

筛选文献、提取资料并按Jadad量表评价文献质量后

采用Rev Man 5.3统计软件针对总有效率、肺动脉收缩压（PASP）、动脉血氧分压（PaO2）和氧合指数（OI）进行荟萃分析（Meta分析）。结果:最终纳入12篇文献

共722例患儿。Meta分析结果显示

研究组患儿的总有效率（RD=0.19

95%CI=0.13～0.24

P<0.000 01）、PaO2（MD=10.54

95%CI=6.89～14.19

P<0.000 01）显著高于对照组

PASP显著低于对照组（MD=-10.24

95%CI=-14.07～-6.40

P<0.000 01）

上述差异均有统计学意义;两组患儿OI的差异无统计学意义（MD=-0.83

95%CI=-5.92～4.26

P=0.75>0.05）。结论:使用抗心力衰竭药米力农能够大幅度提高PPHN患儿的临床治疗总有效率和PaO2

降低PASP

对改善患儿的生活质量大有帮助。

Abstract

OBJECTIVE: To systematically evaluate the clinical efficacy of milinone as anti-heart failure drug in the treatment of persistent pulmonary hypertension of the newborn（ PPHN）

so as to provide reference for the evidence-based medicine and new treatment method.METHODS: PubMed

EMBase

Medline

the Cochrane Library

CNKI

VIP database

Wanfang database and CBM were retrieved to collect the randomized controlled trial（ RCT） of milrinone + conventional treatment（ study group） vs.conventional treatment（ control group） for PPHN.The retrieval time was from the establishment of the database to Oct.2019.The literature were screened

data were extracted and literature quality was evaluated according to the Jadad scale.Total response rate

pulmonary artery systolic pressure（ PASP）

arterial partial oxygen pressure（ PaO

） and oxygenation index（ OI） were analyzed by using RevMan 5.3 statistical software.RESULTS: Totally 12 literature were extracted

including 722 children.Meta-analysis showed that the total effective rate（ RD = 0.19

95%CI = 0.13-0.24

0.000 01） and PaO

（ MD = 10.54

95%CI = 6.89-14.19

0.000 01） of the study group were significantly higher than those of the control group

and PASP was significantly lower than that of the control group（ MD =-10.24

95% CI =-14.07--6.40

0.000 01）

the differences were statistically significant.There was no significant difference in OI between two groups（ MD =-0.83

95% CI =-5.92-4.26

P = 0.75

0.05）.CONCLUSIONS: The application of anti-heart failure drug milrinone can greatly improve the total clinical treatment efficiency and PaO

of children with PPHN

reduce the PASP

and greatly help to improve the quality of life of children.

关键词

米力农新生儿持续性肺动脉高压随机对照试验有效性系统评价

Keywords

MilinonePersistent pulmonary hypertension of the newbornRandomized controlled trialEfficacyMeta-analysis

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