OBJECTIVE: To establish the selective multi-residue detection method for 10 organophosphorus pesticides in 3 kinds of Chinese herbal medicines in Chaoshan.METHODS: Qu EChERS method was used to treat the commonly used Chinese herbal medicines such as Hedyotis diffusa

Perotis and stinky flower in Chaoshan.Gas chromatography-tandem mass spectrometry was used as the analytical method

the selective multi-residue detection method for 10 organophosphorus pesticides was established to analyze the overall residue level and distribution characteristics of organophosphorus pesticides in different Chinese herbal medicines.The risk assessment of organophosphorus pesticide residues was performed.RESULTS: For 10 organophosphorus pesticides in the concentration range from 0.01 μg/ml to 1.0 μg/ml

there was good linear relationship between the mass concentration of organophosphorus pesticide and the peak area.The correlation coefficient（ r2） was from 0.999 3 to 0.999 7

the detection limit was from 1.0 μg/kg to 3.0 μg/kg

the limit of quantification was from 3.3 μg/kg to 10.0 μg/kg.The standard recovery rate was from 90.3% to 98.8%

and the relative standard deviation was from 1.2% to 3.4%.None of the 10 organophosphorus pesticides were detected in the randomly sampled samples of Hedyotis diffusa

Perotis and stinky flowers in Chaoshan

which would not pose an unacceptable long-term dietary intake risk to the general population.CONCLUSIONS: This method has high accuracy and precision

and is suitable for the distribution characteristics and risk assessment of 10 organophosphorus pesticide residues in 3 kinds of Chinese herbal medicines.