OBJECTIVE: To probe into the clinical efficacy of Bailing capsules combined with doxofylline in the treatment of chronic obstructive pulmonary disease（ COPD） in the elderly at stable stage.METHODS: Totally 200 patients with COPD admitted into Dujiangyan People’s Hospital from 2018 to 2019 were extracted to be divided into the control group（ n = 100） and the observation group（ n = 100） via the random number table.Patients in the control group were treated with doxofylline

while the observation group received Bailing capsules combined with doxofylline.Both groups were given continuous treatment for 8 weeks.Clinical efficacy was evaluated after treatment.Traditional Chinese medicine syndrome score

body mass index

obstruction

dyspnea

exercise（ BODE） index and St.George’s respiratory questionnaire（ SGOR） score

forced expiratory volume in one second（ FEV1）

forced vital capacity（ FVC）

serum monocyte chemoattractant protein-1（ MCP-1）

8-Hydroxy-deoxyguanylic acid（ 8-OHdG） levels before and after treatment in both groups were compared.The incidence of adverse drug reactions in both groups was observed.RESULTS: The total effective rate of the observation group was 95.00%（ 95/100）

significantly higher than that of the control group 80.00%（ 80/100）

the difference was statistically significant（ χ2= 10.286

P = 0.001）.Traditional Chinese medicine syndrome score

BODE index and SGOR score of two groups after treatment were significantly lower than those before treatment; traditional Chinese medicine syndrome score

BODE index and SGOR score of the observation group were significantly lower than those of the control group after treatment

and the differences were statistically significant（ P<0.05）.After treatment

FEV1 and FVC of two groups were significantly higher than those before treatment; FEV1 and FVC of the observation group were significantly higher than those of the control group

and the differences were statistically significant（ P<0.05）.The serum levels of MCP-1 and 8-OHdG in two groups were significantly lower than those before the treatment

and those in the observation group were significantly lower than those in the control group

the differences were statistically significant（ P < 0.05）.The incidence of adverse drug reactions in the observation group and control group were respectively 5.00%（ 5/100） and 6.00%（ 6/100）

the difference was not statistically significant（ P>0.05）.CONCLUSIONS: The clinical efficacy of Bailing capsules combined with doxofylline in the treatment of COPD in the elderly at stable stage is significant

which can significantly reduce the clinical symptoms

increase the vital capacity

improve the cognitive function

and has good safety.