Molecular Mechanism of Tanyu Tongzhi Formula in the Treatment of Myocardial Ischemia Reperfusion Injury Based on Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine V2.0

GAO Hongjie; LIU Sihong; GONG Leilei; ZHANG Huamin

doi:10.14009/j.issn.1672-2124.2021.03.004

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Molecular Mechanism of Tanyu Tongzhi Formula in the Treatment of Myocardial Ischemia Reperfusion Injury Based on Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine V2.0

更新时间：2022-10-08

- Molecular Mechanism of Tanyu Tongzhi Formula in the Treatment of Myocardial Ischemia Reperfusion Injury Based on Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine V2.0
- Vol. 21, Issue 3, Pages: 273-277(2021)
- 作者机构：
  
  1. 中国中医科学院中医药信息研究所党委办公室
  2. 首都医科大学附属北京妇产医院药事部
  3. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.03.004
  CLC： R285.5
- Published：2021，
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[1]高宏杰,刘思鸿,贡磊磊,张华敏.基于整合药理学平台V2.0探讨痰瘀同治方抗心肌缺血再灌注损伤的分子机制[J].中国医院用药评价与分析,2021,21(03):273-277.

GAO Hongjie, LIU Sihong, GONG Leilei, et al. Molecular Mechanism of Tanyu Tongzhi Formula in the Treatment of Myocardial Ischemia Reperfusion Injury Based on Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine V2.0. [J]. 21(3):273-277(2021)
[1]高宏杰,刘思鸿,贡磊磊,张华敏.基于整合药理学平台V2.0探讨痰瘀同治方抗心肌缺血再灌注损伤的分子机制[J].中国医院用药评价与分析,2021,21(03):273-277. DOI： 10.14009/j.issn.1672-2124.2021.03.004.

GAO Hongjie, LIU Sihong, GONG Leilei, et al. Molecular Mechanism of Tanyu Tongzhi Formula in the Treatment of Myocardial Ischemia Reperfusion Injury Based on Integrative Pharmacology-Based Research Platform of Traditional Chinese Medicine V2.0. [J]. 21(3):273-277(2021) DOI： 10.14009/j.issn.1672-2124.2021.03.004.

摘要

目的:基于中医药整合药理学平台V2.0（TCMIP V2.0）探讨痰瘀同治方抗心肌缺血再灌注损伤（myocardial ischemia reperfusion injury

MIRI）的分子机制及其质量标志物。方法:利用TCMIP V2.0收集痰瘀同治方药物成分、靶标和MIRI疾病靶标

构建药物与疾病靶标互作网络

筛选药物和疾病共有靶标

并对共有靶标进行生物学过程分析

最后建立"成分-靶标-通路-药理作用"多维网络分析并对网络中的核心成分进行分析。结果:共收集痰瘀同治方中半夏、赤芍、川芎和甘草等药物化学成分157个

相应靶标272个

共收集获得MIRI疾病靶标290个。通过"中医药关联网络挖掘"

对核心靶标中的前100个靶标进行分析

发现药物和疾病共有靶标31个

对共有靶标分析发现

共有靶标主要参与了血管生成的正调控、血管形成、自噬正调控、炎症反应和凋亡负调控等过程。京都基因与基因组百科全书通路富集分析结果显示

共有靶标主要富集于Fox O信号通路、缺氧诱导因子（HIF-1）信号通路、肿瘤坏死因子（TNF）信号通路、PI3K-Akt信号通路及血管内皮生长因子（VEGF）信号通路等信号通路。进一步对多维网络的分析发现

痰瘀同治方中46个成分通过与19个共有靶标作用影响上述5条信号通路发挥抗MIRI作用

其中槲皮素、山奈酚、柚皮素和黄芩素等成分通过干预AKT影响上述5条信号通路参与MIRI发生发展。结论:痰瘀同治方中槲皮素、山奈酚、柚皮素和黄芩素可通过调节炎症反应、自噬与凋亡、氧化应激及血管生成等过程抗MIRI。

Abstract

OBJECTIVE: To investigate the molecular mechanism of Tanyu Tongzhi formula in the treatment of myocardial ischemia reperfusion injury（ MIRI） based on integrative pharmacology-based research platform of traditional Chinese medicine V2.0（ TCMIP V2.0）.METHODS: TCMIP V2.0 was used to collect drug components

targets and MIRI disease targets of Tanyu Tongzhi formula

and drug-disease target interaction network was established.Common targets of drug and disease were screened

and biological process of the common targets was analyzed.Eventually

multidimensional network analysis of "component-target-pathway-pharmacological action " was established and the core components in the network were analyzed.RESULTS: A total of 157 pharmaceutical chemical components were collected

including pinellia ternata

red peony root

Ligusticum wallichii and licorice

and 272 corresponding targets were identified.A total of 290 targets of MIRI were obtained.Through "Traditional Chinese Medicine Association Network Mining"

the first 100 targets in the core targets were analyzed

and 31 targets for drugs and diseases were found.Common targets mainly participated into the positive regulation of angiogenesis

angiogenesis

positive regulation of autophagy

inflammatory response and negative regulation of apoptosis.Kyoto Encyclopedia of Genes and Genome Encyclopedia pathway enrichment analysis showed that the common targets were mainly enriched in FoxO

HIF-1

TNF

PI3 K-Akt and VEGF signaling pathways.Further multidimensional network analysis showed that 46 components in Tanyu Tongzhi formula affected the above 5 signaling pathways by acting with 19 common targets.Quercetin

kaempferol

naringenin and baicalein participated into the occurrence and development of MIRI through 5 signaling pathways by intervention of AKT.CONCLUSIONS: Quercetin

kaempferol

naringenin and baicalein in Tanyu Tongzhi formula can inhibit MIRI by regulating inflammatory response

autophagy and apoptosis

oxidative stress and angiogenesis.

关键词

痰瘀同治方心肌缺血再灌注损伤整合药理学分子机制

Keywords

Tanyu Tongzhi formulaMyocardial ischemia reperfusion injuryIntegrative pharmacology-based research platform of traditional Chinese medicineMolecular mechanism

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