Effects of Cinnamomum Cassia Presl Combined with “Phellodendri Chinensis-Anemarrhenae Rhizoma”on Inflammatory Factors in Rats with Pyelonephritis

WANG Xun; LIU Shun; ZOU Kaiping; LIU Yueheng; ZHU Guangping

doi:10.14009/j.issn.1672-2124.2021.03.001

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Effects of Cinnamomum Cassia Presl Combined with “Phellodendri Chinensis-Anemarrhenae Rhizoma”on Inflammatory Factors in Rats with Pyelonephritis

更新时间：2022-10-08

- Effects of Cinnamomum Cassia Presl Combined with “Phellodendri Chinensis-Anemarrhenae Rhizoma”on Inflammatory Factors in Rats with Pyelonephritis
- Vol. 21, Issue 3, Pages: 257-261(2021)
- 作者机构：
  
  南京中医药大学附属医院制剂部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.03.001
  CLC： R285.5
- Published：2021，
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[1]王迅,刘顺,邹恺平,刘月恒,朱广平.肉桂配伍“黄柏-知母”药对对肾盂肾炎大鼠炎症因子的影响[J].中国医院用药评价与分析,2021,21(03):257-261+268.

WANG Xun, LIU Shun, ZOU Kaiping, et al. Effects of Cinnamomum Cassia Presl Combined with “Phellodendri Chinensis-Anemarrhenae Rhizoma”on Inflammatory Factors in Rats with Pyelonephritis. [J]. 21(3):257-261(2021)
[1]王迅,刘顺,邹恺平,刘月恒,朱广平.肉桂配伍“黄柏-知母”药对对肾盂肾炎大鼠炎症因子的影响[J].中国医院用药评价与分析,2021,21(03):257-261+268. DOI： 10.14009/j.issn.1672-2124.2021.03.001.

WANG Xun, LIU Shun, ZOU Kaiping, et al. Effects of Cinnamomum Cassia Presl Combined with “Phellodendri Chinensis-Anemarrhenae Rhizoma”on Inflammatory Factors in Rats with Pyelonephritis. [J]. 21(3):257-261(2021) DOI： 10.14009/j.issn.1672-2124.2021.03.001.

摘要

目的:探讨肉桂配伍"黄柏-知母"药对对肾盂肾炎大鼠肾脏及血清样本中炎症因子的影响

初步探讨肉桂反佐配伍治疗肾盂肾炎的分子机制。方法:建立肾盂肾炎大鼠模型

设立对照组、模型组、阳性药组（采用盐酸左氧氟沙星）、滋肾通关方组（采用肉桂配伍"黄柏-知母"药对）及药对组（采用单纯"黄柏-知母"药对）进行比较;以酶联免疫吸附试剂盒检测炎症因子[白细胞介素（IL）1α、IL-1β、肿瘤坏死因子α（TNF-α）、IL-6、单核细胞趋化蛋白1（MCP-1）、CXCL2]在各组大鼠血清中的含量

进行药效学考察。结果:（1）阳性药组、滋肾通关方组及药对组大鼠机体状况均有改善。通过比较病理切片

滋肾通关方组与阳性药组大鼠的改善情况明显优于"黄柏-知母"药对组。（2）模型组大鼠的IL-1α、IL-1β、TNF-α、IL-6、MCP-1及CXCL2含量均较对照组更高

而且模型组大鼠血清IL-α、CXCL2含量与对照组比较

差异均有统计学意义（P<0.05）。（3）阳性药组、滋肾通关方组及药对组大鼠体内炎症因子含量相对模型组均有降低;其中

滋肾通关方组大鼠血清IL-1α含量、阳性药组大鼠血清TNF-α含量与模型组的差异均有统计学意义（P<0.05）。结论:"黄柏-知母"药对反佐配伍少量肉桂后

能够促进黄柏、知母中活性成分下调IL-1α、IL-1β、TNF-α、IL-6、MCP-1及CXCL2等炎症因子的表达

影响下游炎症因子的免疫应答

进而起到抗炎以及保护肾脏等泌尿系统器官的作用。

Abstract

OBJECTIVE: To probe into the effects of Cinnamomum cassia Presl combined with "Phellodendri Chinensis-Anemarrhenae Rhizoma"on inflammatory factors in kidney and serum samples of rats with pyelonephritis

and to explore the molecular mechanism of Cinnamomum cassia Presl in the treatment of pyelonephritis.METHODS:Rat model of pyelonephritis was established

the control group

model group

positive drug group（ levofloxacin hydrochloride）

Zishen Tongguan prescription group（ Cinnamomum cassia Presl combined with "Phellodendri Chinensis-Anemarrhenae Rhizoma"） and drug combination group（ "Phellodendri Chinensis-Anemarrhenae Rhizoma"）were compared.Serum concentrations of inflammatory factors [interleukin（ IL） 1α

IL-1β

tumor necrosis factor α（ TNF-α）

IL-6

monocyte chemotaxis protein 1（ MCP-1）

CXCL2] in each group were determined by ELISA for pharmacodynamic study.RESULTS:（ 1） The disease condition of rats in the positive drug group

Zishen Tongguan prescription group and drug combination group was improved.Through the comparison of pathological sections

the improvement of rats in the Zishen Tongguan prescription group and the positive drug group was significantly better than that of the"Phellodendri Chinensis-Anemarrhenae Rhizoma"drug combination group.（ 2） The levels of IL-1α

IL-1β

TNF-α

IL-6

MCP-1 and CXCL2 in the model group were higher than those in the control group

and there were statistically significant differences in the levels of IL-1α and CXCL2 in serum of the model group and the control group（ P<0.05）.（ 3） Compared with model group

the levels of inflammatory factors in the positive drug group

Zishen Tongfang prescription group and drug combination group decreased; compared with the model group

there were significant differences in levels of IL-1α in the Zisheng Tongfang prescription group and levels of TNF-α in the positive drug group（ P < 0.05）.CONCLUSIONS: "Phellodendri Chinensis-Anemarrhenae Rhizoma " combined with Cinnamomum cassia Presl can promote the active components of Phellodendri Chinensis and Anemarrhenae Rhizoma to down-regulate the expression of inflammatory factors such as IL-1α

IL-1β

TNF-α

IL-6

MCP-1 and CXCL2

affect the immune response of downstream inflammatory factors

and then play an role in anti-inflammatory and protective effect on the kidney and other urinary systems.

关键词

滋肾通关方反佐肾盂肾炎炎症因子

Keywords

Zishen Tongguan prescriptionCorrigentPyelonephritisInflammatory factors

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