Analysis and Discussion of 858 Cases of Adverse Drug Reactions Induced by Contrast Mediums

WANG Ying; LU Meng; CHEN Xingwei; DING Zheng; ZHENG Yingli

doi:10.14009/j.issn.1672-2124.2021.02.030

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Analysis and Discussion of 858 Cases of Adverse Drug Reactions Induced by Contrast Mediums

更新时间：2022-10-08

- Analysis and Discussion of 858 Cases of Adverse Drug Reactions Induced by Contrast Mediums
- Vol. 21, Issue 2, Pages: 250-252(2021)
- 作者机构：
  
  中国医学科学院阜外医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.02.030
  CLC： R95
- Published：2021，
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[1]王莹,芦梦,陈星伟,丁征,郑英丽.858例对比剂致药品不良反应报告分析及探讨[J].中国医院用药评价与分析,2021,21(02):250-252+256.

WANG Ying, LU Meng, CHEN Xingwei, et al. Analysis and Discussion of 858 Cases of Adverse Drug Reactions Induced by Contrast Mediums. [J]. 21(2):250-252(2021)
[1]王莹,芦梦,陈星伟,丁征,郑英丽.858例对比剂致药品不良反应报告分析及探讨[J].中国医院用药评价与分析,2021,21(02):250-252+256. DOI： 10.14009/j.issn.1672-2124.2021.02.030.

WANG Ying, LU Meng, CHEN Xingwei, et al. Analysis and Discussion of 858 Cases of Adverse Drug Reactions Induced by Contrast Mediums. [J]. 21(2):250-252(2021) DOI： 10.14009/j.issn.1672-2124.2021.02.030.

摘要

目的:了解及评价对比剂相关药品不良反应（adverse drug reaction

ADR）发生特点及规律

并提出防治措施

为临床对比剂的安全使用提供参考。方法:回顾性总结和分析2010—2018年中国医学科学院阜外医院（以下简称"我院"）进行影像学检查时使用对比剂发生ADR的报告。结果:2010—2018年我院共上报ADR报告1 257例

其中对比剂致ADR报告858例（占68.26%）

涉及对比剂5个品种

均为非离子型碘对比剂; ADR报告数排序居前3位的对比剂分别为碘普罗胺、碘海醇和碘克沙醇;对比剂致ADR以过敏反应为主

主要表现为皮疹、瘙痒、荨麻疹、面部潮红及口眼肿胀等。结论:对比剂在我院临床使用的安全性总体良好;用药过程中应密切观察

出现急性或严重的过敏反应时要准确识别、认真对待

做到及时正确救治

最大限度地保障患者的生命安全。

Abstract

OBJECTIVE: To investigate and evaluate the occurrence characteristics and rules of adverse drug reaction（ ADR） induced by contrast mediums

and put forward prevention and treatment measures to provide reference for the safe use of contrast mediums in clinic. METHODS: Reports of ADR induced by contrast mediums in imaging examinations in Fuwai Hospital

Chinese Academy of Medical Sciences（ hereinafter referred to as"our hospital"） from2010 to 2018 were retrospectively summarized and analyzed.RESULTS: A total of 1 257 cases of ADR were reported in our hospital from 2010 to 2018

among which 858 cases（ 68. 26%） were reported as ADR induced by contrast mediums

including 5 types of contrast mediums（ non-ionic iodine contrast mediums）. The top 3 contrast mediums ranked by the number of ADR reports were respectively iopromide

iohexol and iodixanol. ADR induced by contrast mediums was mainly allergic reactions

mainly manifested as rash

pruritus

urticaria

facial flushing and mouth and eye swelling.CONCLUSIONS: The safety of contrast mediums in clinical use in our hospital is generally good; close observation should be made during the medication process

and acute or severe allergic reactions should be accurately identified and treated seriously to ensure timely and correct treatment to maximize the safety of patients.

关键词

药品不良反应对比剂影像学合理用药

Keywords

Adverse drug reactionsContrast mediumIconographyRational drug use

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