OBJECTIVE: To probe into the clinical efficacy of Jinzhen oral liquid combined with Yanhuning for injection in the treatment of children with viral pneumonia and its effects on symptoms and signs

levels of inflammatory factors and lung function. METHODS: Totally 210 children with viral pneumonia admitted into Nanjing Tongren Hospital Affiliated to Southeast University from Mar. 2017 to May 2020 were extracted to be divided into the combination group（ n = 105） and the control group（ n = 105） via the random number table. The control group was treated with Yanhuning for injection

while the combination group received Yanhuning for injection combined with Jinzhen oral liquid. The clinical efficacy

symptom and sign score（ body temperature

shortness of breath

cough and lung rale）

serum levels of inflammatory factors such as tumor necrosis factor α（ TNF-α）

hypersensitive C-reactive protein（ hs-CRP） and interleukin-8（ IL-8）

lung function indexes before and after treatment and the incidence of adverse drug reactions in two groups were observed. RESULTS: The total effective rate in the combination group was significantly higher than that in the control group[96. 19%（ 101/105） vs. 85. 71%（ 90/105） ]

the difference was statistically significant（ P

<

0. 05）. After treatment

the scores of body temperature

shortness of breath

cough and lung rale of two groups were significantly lower than those before treatment

and the scores of body temperature

shortness of breath

cough and lung rale of the combination group were significantly lower than those of the control group

the differences were statistically significant（ P

<

0. 05）. After treatment

the serum levels of TNF-α

hs-CRP and IL-8 in two groups were significantly lower than those before treatment

and the combination group was significantly lower than the control group

with statistical significance（ P

<

0. 05）. After treatment

forced vital capacity（ FVC）

forced expiratory volume in 1 second（ FEV

1

） and FEV

1

/FVC in two groups increased significantly compared with before treatment

and FVC

FEV

1

and FEV

1

/FVC in the combination group were significantly higher than those in the control group

with statistically significant difference（ P

<

0. 05）. The total incidence of adverse drug reactions in the combination group was 7. 62%（ 8/105）

compared with 5. 71%（ 6/105） in the control group

the difference was not statistically significant（ P

>

0. 05）. CONCLUSIONS: The clinical efficacy of Jinzhen oral liquid combined with Yanhuning for injection in the treatment of children with viral pneumonia is significant

which can effectively relieve the clinical symptoms and signs

reduce the levels of inflammatory factors

and improve lung function with higher safety.