OBJECTIVE: To probe into the clinical efficacy of Selenium yeast tablets combined with Baoyuan capsules in the treatment of chronic lymphocytic thyroiditis and its effects on lymphocyte subsets and thyroid autoantibodies. METHODS: Totally 146 patients with chronic lymphocytic thyroiditis admitted into Shijiazhuang Hospital of Traditional Chinese Medicine from Nov. 2016 to Jan. 2020 were extracted to be divided into the observation group and the control group via the random number table

with 73 cases in each group. The control group was treated with Levothyroxine tablets

while the observation group received Selenium yeast tablets combined with Baoyuan capsules based on the control group. Both groups were treated for 6 months. The improvement of traditional Chinese medicine syndromes

thyroid volume

the incidence of adverse reactions

levels of T lymphocyte subsets

thyroid hormones and antibodies [serum free triiodothyronine（ FT

3

）

serum free thyroxine（ FT

4

）

thyroid stimulating hormone（ TSH）

thyroid peroxidase antibody（ TPOAb） and thyroid globulin antibody（ TgAb） ]in two groups were observed. RESULTS: After 6 months of treatment

the improvement of anterior lump

pale complexion

fatigue

poor appetite

anorexia and frequent urination in the observation group was better than that in the control group; the levels of TSH

TgAb and TPOAb in the observation group were significantly lower than those in the control group

while the levels of FT

3

and FT

4

were significantly higher than those of the control group

the difference was statistically significant（ P

<

0. 05）. After treatment

the thickness of left and right lobes and isthmus of thyroid decreased in both groups

yet there was no statistical significance compared with that before treatment

and after treatment between two groups（ P

>

0. 05）. After 3 and 6 months of treatment

the levels of CD3

+

CD4

+

and CD4

+

/CD8

+

in the observation group were significantly higher than those in the control group

while the levels of CD8

+

were significantly lower than those in the control group

with statistically significant difference（ P

<

0. 05）. During the treatment

neither of two groups encountered significant adverse drug reactions.CONCLUSIONS: The clinical efficacy of Selenium yeast tablets combined with Baoyuan capsules in the treatment of chronic lymphocytic thyroiditis is significant

which can effectively reduce the level of thyroid autoantibodies and improve the disorder of T lymphocyte subsets.