Comparison of Efficacy and Pathogen Clearance Rate of Different Dosing Frequency of Cefoperazone Sodium and Sulbactam Sodium in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

ZHAO Xiaofei; BAI Jing; JIANG Xin; REN Liyuan; LI Xin; AN Meng; LIU Rongge

doi:10.14009/j.issn.1672-2124.2021.01.013

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Comparison of Efficacy and Pathogen Clearance Rate of Different Dosing Frequency of Cefoperazone Sodium and Sulbactam Sodium in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

更新时间：2022-10-08

- Comparison of Efficacy and Pathogen Clearance Rate of Different Dosing Frequency of Cefoperazone Sodium and Sulbactam Sodium in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Vol. 21, Issue 1, Pages: 49-52(2021)
- 作者机构：
  
  1. 邢台医学高等专科学校第二附属医院临床药学科
  2. 石家庄第二医院药剂科
  3. 河北省民政总医院药剂科
  4. 邢台医学高等专科学校第二附属医院感染管理科
  5. 邢台医学高等专科学校第二附属医院重症医学科
  6. 河北省南和县疾病预防控制中心
  7. 邢台医学高等专科学校第二附属医院呼吸与危重症医学科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.01.013
  CLC： R563.9
- Published：2021，
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[1]赵晓飞,白晶,江欣,任丽媛,李欣,安蒙,刘荣格.头孢哌酮钠舒巴坦钠不同给药频次用于慢性阻塞性肺疾病急性加重期患者的疗效及病原菌清除率比较[J].中国医院用药评价与分析,2021,21(01):49-52+58.

ZHAO Xiaofei, BAI Jing, JIANG Xin, et al. Comparison of Efficacy and Pathogen Clearance Rate of Different Dosing Frequency of Cefoperazone Sodium and Sulbactam Sodium in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. [J]. 21(1):49-52(2021)
[1]赵晓飞,白晶,江欣,任丽媛,李欣,安蒙,刘荣格.头孢哌酮钠舒巴坦钠不同给药频次用于慢性阻塞性肺疾病急性加重期患者的疗效及病原菌清除率比较[J].中国医院用药评价与分析,2021,21(01):49-52+58. DOI： 10.14009/j.issn.1672-2124.2021.01.013.

ZHAO Xiaofei, BAI Jing, JIANG Xin, et al. Comparison of Efficacy and Pathogen Clearance Rate of Different Dosing Frequency of Cefoperazone Sodium and Sulbactam Sodium in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. [J]. 21(1):49-52(2021) DOI： 10.14009/j.issn.1672-2124.2021.01.013.

摘要

目的:比较头孢哌酮钠舒巴坦钠不同给药频次用于慢性阻塞性肺疾病急性加重期患者的疗效及对病原菌清除率的影响

为临床慢性阻塞性肺疾病患者合理应用抗菌药物提供指导。方法:选取2018年1月至2019年1月邢台医学高等专科学校第二附属医院收治的慢性阻塞性肺疾病急性加重期患者120例

以随机数字表分为研究组（n=60）和对照组（n=60）。研究组患者采用头孢哌酮钠舒巴坦钠3.0 g

每8 h给药1次;对照组患者采用头孢哌酮钠舒巴坦钠3.0 g

每12 h给药1次;两组患者均治疗10 d。观察两组患者的临床疗效、第1 s用力呼气容积（FEV1）、FEV1占用力肺活量百分比（FEV1/FVC）、血氧饱和度、动脉血氧分压、睡眠效果评分、临床症状恢复时间、实验室检查指标恢复时间、血清杀菌活性（SBA）及病原菌清除率。结果:研究组患者的临床总有效率为98.33%（59/60）

明显高于对照组的90.00%（54/60）

差异有统计学意义（P <0.05）。研究组患者的FEV1、FEV1/FCV、血氧饱和度、动脉血氧分压及睡眠效果评分明显优于对照组

发热、咳嗽、C反应蛋白及中性粒细胞恢复时间明显短于对照组

峰时和谷时SBA明显高于对照组

差异均有统计学意义（P <0.05）。研究组患者的病原菌清除率为88.46%（46/52）

明显高于对照组的66.00%（33/50）

差异有统计学意义（P <0.05）。结论:头孢哌酮钠舒巴坦钠每8 h给药1次可提高慢性阻塞性肺疾病急性加重期患者的临床疗效

改善肺功能

提高病原菌清除率

且对铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌及鲍曼不动杆菌的SBA高于每12 h给药1次。

Abstract

OBJECTIVE: To compare the efficacy of different dosing frequency of cefoperazone sodium and sulbactam sodium in patients with acute exacerbation of chronic obstructive pulmonary disease and its effects on pathogen clearance rate

so as to provide guidance for the rational use of antibiotics for patients with chronic obstructive pulmonary disease in clinic. METHODS: Totally 120 patients with acute exacerbation of chronic obstructive pulmonary disease admitted into the Second Affiliated Hospital of Xingtai Medical College from Jan. 2018 to Jan. 2019 were extracted to be divided into the study group（ n = 60） and the control group（ n = 60） via the random number table.The study group was treated with cefoperazone sodium and sulbactam sodium 3. 0 g once every 8 hours

while the control group received cefoperazone sodium and sulbactam sodium 3. 0 g once every 12 hours. Both groups were treated for 10 d.The clinical efficacy

forced expiratory volume in one second（ FEV1）

FEV1/FVC

blood oxygen saturation

arterial partial pressure of oxygen and sleep score

recovery time of clinical symptoms

recovery time of laboratory examination

serum bactericidal activity（ SBA） and pathogen clearance rate of two groups were observed. RESULTS: The total clinical effective rate was 98. 33%（ 59/60） in the study group

significantly higher than 90. 00%（ 54/60） in the control group

with statistically significant difference（ P < 0. 05）. FEV1

FEV1/FCV

blood oxygen saturation

arterial partial pressure of oxygen and sleep scores of the study group were significantly better than those of the control group

and the recovery time of fever

cough

C-reactive protein and neutrophil was significantly shorter than that of the control group

SBA at peak and valley time was significantly higher than that of the control group

the difference was statistically significant（ P < 0. 05）. The pathogen clearance rate in the study group was 88. 46%（ 46/52）

significantly higher than66. 00%（ 33/50） in the control group

with statistically significant difference（ P < 0. 05）. CONCLUSIONS:Treatment with cefoperazone sodium and sulbactam sodium every 8 hours can significantly improve the clinical efficacy of patients with chronic obstructive pulmonary disease

and effectively improve lung function and pathogen clearance

the SBA of Pseudomonas aeruginosa

Klebsiella pneumoniae

Escherichia coli and Acinetobacter baumannii is higher than treatment with cefoperazone sodium and sulbactam sodium every 12 hours.

关键词

头孢哌酮钠舒巴坦钠给药频次慢性阻塞性肺疾病急性加重期临床疗效SBA病原菌清除率

Keywords

Cefoperazone sodium and sulbactam sodiumDosing frequencyAcute exacerbation of chronic obstructive pulmonary diseaseClinical efficacySBAPathogen clearance rate

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