Effects of Recombinant Human Brain Natriuretic Peptide Combined with Nicorandil on Cardiac Function and Serum NO and ET-1 Levels in Patients with Ischemic Heart Failure

LI Xin; LI Xiaozeng; QIAO Xiangling; ZHANG Qingqing; MIAO Bo; QI Liping

doi:10.14009/j.issn.1672-2124.2021.01.010

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Effects of Recombinant Human Brain Natriuretic Peptide Combined with Nicorandil on Cardiac Function and Serum NO and ET-1 Levels in Patients with Ischemic Heart Failure

更新时间：2022-10-08

- Effects of Recombinant Human Brain Natriuretic Peptide Combined with Nicorandil on Cardiac Function and Serum NO and ET-1 Levels in Patients with Ischemic Heart Failure
- Vol. 21, Issue 1, Pages: 38-40(2021)
- 作者机构：
  
  邢台市第三医院心内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.01.010
  CLC： R541.6
- Published：2021，
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[1]李欣,李晓增,乔香玲,张青青,苗博,齐丽平.重组人脑利钠肽联合尼可地尔对缺血性心力衰竭患者心脏功能及血清一氧化氮、内皮素水平的影响[J].中国医院用药评价与分析,2021,21(01):38-40+44.

LI Xin, LI Xiaozeng, QIAO Xiangling, et al. Effects of Recombinant Human Brain Natriuretic Peptide Combined with Nicorandil on Cardiac Function and Serum NO and ET-1 Levels in Patients with Ischemic Heart Failure. [J]. 21(1):38-40(2021)
[1]李欣,李晓增,乔香玲,张青青,苗博,齐丽平.重组人脑利钠肽联合尼可地尔对缺血性心力衰竭患者心脏功能及血清一氧化氮、内皮素水平的影响[J].中国医院用药评价与分析,2021,21(01):38-40+44. DOI： 10.14009/j.issn.1672-2124.2021.01.010.

LI Xin, LI Xiaozeng, QIAO Xiangling, et al. Effects of Recombinant Human Brain Natriuretic Peptide Combined with Nicorandil on Cardiac Function and Serum NO and ET-1 Levels in Patients with Ischemic Heart Failure. [J]. 21(1):38-40(2021) DOI： 10.14009/j.issn.1672-2124.2021.01.010.

摘要

目的:探讨重组人脑利钠肽与尼可地尔联合应用对缺血性心力衰竭患者心脏功能及血清一氧化氮（NO）、内皮素（ET-1）含量的影响。方法:筛选2019年5月至2020年3月邢台市第三医院收治的缺血性心力衰竭患者100例

采用随机数字表法将其分为对照组（n=50）和研究组（n=50）。对照组患者采用常规疗法+重组人脑利钠肽治疗

研究组患者在对照组的基础上加用尼可地尔进行治疗。观察治疗4周后两组患者的心脏功能

监测血清NO和ET-1含量变化和不良反应发生情况。结果:治疗后

两组患者的心脏功能均明显好转

但研究组患者的总有效率为96%（48/50）

明显高于对照组的88%（44/50）

差异有统计学意义（P <0.05）。治疗后

研究组患者左心室收缩末期内径、左心室舒张末期内径明显低于对照组

而左心室射血分数则较对照组明显升高

差异均有统计学意义（P <0.05）。与对照组比较

研究组患者治疗后的血清NO含量明显升高

而血清ET-1含量则明显降低

差异均有统计学意义（P <0.05）。研究组、对照组患者的不良反应发生率分别为10%（5/50）、12%（6/50）

差异无统计学意义（P> 0.05）。结论:重组人脑利钠肽与尼可地尔联合治疗缺血性心力衰竭的疗效显著

可从多途径改善患者的心功能

且不增加不良反应。

Abstract

OBJECTIVE: To probe into the effects of recombinant human brain natriuretic peptide combined with nicorandil on cardiac function and serum nitric oxide（ NO）

endothelin（ ET-1） levels in patients with ischemic heart failure. METHODS: Totally 100 patients with ischemic heart failure admitted into Xingtai Third Hospital from May2019 to Mar. 2020 were extracted to be divided into the control group（ n = 50） and the study group（ n = 50） via the random number table. The control group was treated with conventional therapy + recombinant human brain natriuretic peptide

while the study group received nicorandil on the basis of the control group. The cardiac function of two groups was observed after treatment of 4 weeks

and the changes of serum NO and ET-1 levels and the occurrence of adverse drug reactions were monitored. RESULTS: The cardiac function of both groups was significantly improved

yet the total effective rate of the study group was 96%（ 48/50）

significantly higher than that in the control group（ 88%

44/50）

with statistically significant difference（ P < 0. 05）. After treatment

the left ventricular end-systolic and end-diastolic diameters in the study group were significantly lower than those in the control group

while the left ventricular ejection fraction was significantly higher than that in the control group

with statistically significant differences（ P < 0. 05）.Compared with the control group

the serum NO in the study group increased significantly after treatment

while the serum ET-1 decreased significantly

with statistically significant differences（ P < 0. 05）. The incidences of adverse drug reactions in the study group and the control group were respectively 10%（ 5/50） and 12%（ 6/50）

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The efficacy of recombinant human brain natriuretic peptide combined with nicorandil in the treatment of schemic heart failure is significant

which can improve the cardiac function in multiple ways without increasing the incidence of adverse drug reactions.

关键词

重组人脑利钠肽尼可地尔缺血性心力衰竭心功能

Keywords

Recombinant human brain natriuretic peptideNicorandilIschemic heart failureCardiac function

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