Systematic Review of Efficacy of Osteopeptide Injection in the Adjuvant Treatment of Postoperative Healing of Limb Fracture

LI Sha’en; CHEN Zhongchun; DUAN Fujun; ZHANG Yongxin

doi:10.14009/j.issn.1672-2124.2020.12.019

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Systematic Review of Efficacy of Osteopeptide Injection in the Adjuvant Treatment of Postoperative Healing of Limb Fracture

更新时间：2022-10-08

- Systematic Review of Efficacy of Osteopeptide Injection in the Adjuvant Treatment of Postoperative Healing of Limb Fracture
- Vol. 20, Issue 12, Pages: 1483-1486(2020)
- 作者机构：
  
  1. 中国人民解放军南部战区空军医院门诊部
  2. 中国人民解放军南部战区空军医院药剂科
  3. 中国人民解放军南部战区空军医院空勤科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.12.019
  CLC： R687.3
- Published：2020，
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[1]李莎恩,陈仲春,段付军,张永昕.骨肽注射液辅助用于四肢骨折术后愈合疗效的系统评价[J].中国医院用药评价与分析,2020,20(12):1483-1486+1492.

LI Sha’en, CHEN Zhongchun, DUAN Fujun, et al. Systematic Review of Efficacy of Osteopeptide Injection in the Adjuvant Treatment of Postoperative Healing of Limb Fracture. [J]. 20(12):1483-1486(2020)
[1]李莎恩,陈仲春,段付军,张永昕.骨肽注射液辅助用于四肢骨折术后愈合疗效的系统评价[J].中国医院用药评价与分析,2020,20(12):1483-1486+1492. DOI： 10.14009/j.issn.1672-2124.2020.12.019.

LI Sha’en, CHEN Zhongchun, DUAN Fujun, et al. Systematic Review of Efficacy of Osteopeptide Injection in the Adjuvant Treatment of Postoperative Healing of Limb Fracture. [J]. 20(12):1483-1486(2020) DOI： 10.14009/j.issn.1672-2124.2020.12.019.

摘要

目的:基于文献荟萃分析（Meta分析）方法

系统评价骨肽注射液辅助用于四肢骨折术后的临床效果

以期更有效地指导临床。方法:检索中国知网（CNKI）、维普数据库（VIP）、中国生物医学文献服务系统（SinoMed）、万方数据库、中国临床试验注册中心（ChiCTR）、PubMed、EMBase以及Cochrane图书馆等数据库

检索时间为建库至2020年3月

纳入骨肽注射液辅助用于四肢骨折术后的随机对照试验（观察组患者的干预措施为使用骨肽注射液

对照组患者不使用骨肽注射液

两组患者可同时使用药物或其他治疗）

按照改良Jadad质量计分法对纳入的临床随机对照试验进行方法学质量评估

采用Stata 15.0软件进行Meta分析。结果:共纳入5篇符合分析要求的临床随机对照试验

涉及444例患者

其中观察组患者222例

对照组患者222例。Meta分析结果显示

使用骨肽注射液辅助用于四肢骨折术后的观察组患者的好转率显著优于对照组

差异有统计学意义（OR=2.62

95%CI=1.84～3.73

P<0.01）;其中

有2篇文献报道了观察组患者的不良反应

经简单对症处理后治愈

无明显后遗症状。结论:骨肽注射液辅助用于四肢骨折术后

可提高好转率

且安全性较高

建议在临床中根据患者实际情况使用

且使用过程中观察药品不良反应。目前仅有相关中文资料

有价值的论文数有限

本研究结果仍需高质量的临床研究加以验证。

Abstract

OBJECTIVE:To systematically evaluate the clinical effects of osteopeptide injection in the adjuvant treatment of postoperative healing of limb fracture based on Meta-analysis

so as to guide the clinical practice more effectively.METHODS:CNKI

VIP

SinoMed

Wanfang database

ChiCTR

PubMed

EMBase

the Cochrane Library and other databases were retrieved to collect the randomized controlled trial of osteopeptide injection in the adjuvant treatment of postoperative limb fracture（the intervention measures of the observation group were osteopeptide injection

while the control group did not use osteopeptide injection

both groups could be treated with drugs or other treatments at the same time）.The retrieval time was from establishment of the database to Mar.2020.Methodological quality evaluation of the randomized controlled clinical trial was carried out according to the improved Jadad quality scoring method

and Meta-analysis was performed by using Stata 15.0 software.RESULTS:A total of 5 clinical randomized controlled trials were collected

including 444 patients

there were 222 patients in the observation group and 222 patients in the control group.Meta-analysis results showed that the improvement rate of osteopeptide injection in the adjuvant treatment of postoperative limb fractures in the observation group was significantly better than that in the control group

with statistically significant difference（OR=2.62

95% CI=1.84-3.73

P <0.01）.Two articles reported adverse drug reactions in the observation group

which were cured after simple symptomatic treatment without obvious sequelae symptoms.CONCLUSIONS:Osteopeptide injection can improve the improvement rate and has higher safety in the treatment of postoperative limb fractures.It is recommended that osteopeptide injection should be used in clinic according to the actual situation of patients

and adverse drug reactions should be observed.Currently

only relevant Chinese data are available

and the number of valuable papers is limited.The results of this study still need to be verified by high-quality clinical studies.

关键词

骨肽注射液四肢骨折随机对照试验Meta分析

Keywords

Oteopeptide injectionFracture of limbsRandomized controlled trialMeta-analysis

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