Systematic Review and Clinical Analysis of Blurred Vision Induced by Penehyclidine Hydrochloride Injection

XUE Wenxin; LI Jing; ZONG Dongjiang; SUN Jinwen; WANG Yingli; LI Lei

doi:10.14009/j.issn.1672-2124.2020.12.018

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Systematic Review and Clinical Analysis of Blurred Vision Induced by Penehyclidine Hydrochloride Injection

更新时间：2022-10-08

- Systematic Review and Clinical Analysis of Blurred Vision Induced by Penehyclidine Hydrochloride Injection
- Vol. 20, Issue 12, Pages: 1478-1482(2020)
- 作者机构：
  
  1. 应急总医院药学部
  2. 应急总医院普外肿瘤科
  3. 应急总医院眼科
  4. 应急总医院麻醉科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.12.018
  CLC： R969
- Published：2020，
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[1]薛文鑫,李静,宗东江,孙劲文,王应利,李蕾.盐酸戊乙奎醚注射液致视物模糊的系统评价与临床分析[J].中国医院用药评价与分析,2020,20(12):1478-1482.

XUE Wenxin, LI Jing, ZONG Dongjiang, et al. Systematic Review and Clinical Analysis of Blurred Vision Induced by Penehyclidine Hydrochloride Injection. [J]. 20(12):1478-1482(2020)
[1]薛文鑫,李静,宗东江,孙劲文,王应利,李蕾.盐酸戊乙奎醚注射液致视物模糊的系统评价与临床分析[J].中国医院用药评价与分析,2020,20(12):1478-1482. DOI： 10.14009/j.issn.1672-2124.2020.12.018.

XUE Wenxin, LI Jing, ZONG Dongjiang, et al. Systematic Review and Clinical Analysis of Blurred Vision Induced by Penehyclidine Hydrochloride Injection. [J]. 20(12):1478-1482(2020) DOI： 10.14009/j.issn.1672-2124.2020.12.018.

摘要

目的:基于系统评价和案例分析

探讨盐酸戊乙奎醚注射液引发视物模糊的临床特点及预后。方法:收集应急总医院上报的盐酸戊乙奎醚注射液引起视物模糊的病例

同时检索建库至2018年9月中国知网、万方数据库及中国生物医学文献数据库收录的关于盐酸戊乙奎醚注射液引起视物模糊的个案报告或临床研究。结果:（1）系统评价。纳入系统评价的临床研究文献共6篇（涉及患者710例）

结果显示

戊乙奎醚致视物模糊发生率与东莨菪碱（OR=1.60

95%CI=0.75～3.39

P=0.22）、阿托品（OR=1.24

95%CI=0.58～2.67

P=0.58）的差异均无统计学意义。（2）案例分析。共纳入盐酸戊乙奎醚注射液引发视物模糊的病例10例

其中女性9例

男性1例;年龄8～82岁

其中青年人（18～40岁）最多（7例

占70%）;盐酸戊乙奎醚注射液的用药目的

8例为麻醉前用药

2例用于解除胃肠道痉挛;盐酸戊乙奎醚注射液的给药剂量为0.3～2 mg

1例老年患者超量使用;盐酸戊乙奎醚注射液的给药方法为静脉注射和肌内注射;患者用药后表现为视近物模糊

自行好转

持续时间约16 h至7 d:10例患者的不良反应关联性评价结果均为"很可能"。结论:盐酸戊乙奎醚注射液引起视物模糊多发生于青年女性

其致视物模糊发生率与东莨菪碱、阿托品相当

临床表现为视近物模糊

持续时间约1周

无需特殊处理

可自行好转

预后良好。

Abstract

OBJECTIVE:To probe into the clinical characteristics and prognosis of blurred vision induced by penehyclidine hydrochloride injection based on systematic review and clinical analysis.METHODS:The cases of blurred visual induced by penehyclidine hydrochloride injection in Emergency General Hospital was collected and retrieved by CNKI

Wanfang database and CBM until Sept.2018.RESULTS:（1） Systematic review.A total of 6 clinical studies were included in the systematic review（710 patients）.There was no significant difference between the incidence of blurred vision induced by penehydramnios hydrochloride injection and scopolamine（OR=1.60

95%CI=0.75-3.39

P=0.22） and atropine（OR=1.24

95%CI=0.58-2.67

P=0.58）.（2） Clinical analysis.A total of 10 cases of blurred vision induced by penehyclidine hydrochloride injection were included

including 9 females and 1 male

aged 8 to 82 years

of which young people（from 18 to 40 years） were the most（7 cases

70%）.In terms of purpose of administration of penehyclidine hydrochloride injection

8 cases were treated before anesthesia and 2 cases were treated for gastrointestinal spasm relief.The dosage of penehyclidine hydrochloride injection was from 0.3 to2 mg

which was overused in one elderly patient.The administration method of penehyclidine hydrochloride injection was intravenous injection and intramuscular injection.The patient showed blurred vision after taking penehyclidine hydrochloride injection and self-improvement

lasting for 16 h to 7 d:the evaluation results of the relevance of adverse drug reactions in 10 patients were " probable".CONCLUSIONS:Blurred vision induced by penehyclidine hydrochloride injection mostly occurs in young women.The incidence of blurred vision induced by penehyclidine hydrochloride injection is similar to that of scopolamine and atropine

and the clinical manifestation is near-blurriness

lasting for 1 week

and no special treatment is needed

which can get better on its own with good prognosis.

关键词

戊乙奎醚视物模糊不良反应系统评价

Keywords

Penehyclidine hydrochloride injectionBlurred visionAdverse reactionsSystematic review

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