Evidence-Based Pharmacoeconomic Evaluation of Qishen Yiqi Dripping Pills in the Treatment of Chronic Heart Failure

LI Xuejing; ZHANG Huiling; WANG Xiaoli; GAO Shengnan; LIU Yang; LIU Guoqiang

doi:10.14009/j.issn.1672-2124.2020.12.017

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Evidence-Based Pharmacoeconomic Evaluation of Qishen Yiqi Dripping Pills in the Treatment of Chronic Heart Failure

更新时间：2022-10-08

- Evidence-Based Pharmacoeconomic Evaluation of Qishen Yiqi Dripping Pills in the Treatment of Chronic Heart Failure
- Vol. 20, Issue 12, Pages: 1472-1477(2020)
- 作者机构：
  
  1. 河北医科大学第三医院药剂科
  2. 河北医科大学第三医院中医科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.12.017
  CLC： R259
- Published：2020，
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[1]李雪靖,张慧玲,王晓丽,高胜男,刘洋,刘国强.芪参益气滴丸治疗慢性心力衰竭的循证药物经济学评价[J].中国医院用药评价与分析,2020,20(12):1472-1477+1482.

LI Xuejing, ZHANG Huiling, WANG Xiaoli, et al. Evidence-Based Pharmacoeconomic Evaluation of Qishen Yiqi Dripping Pills in the Treatment of Chronic Heart Failure. [J]. 20(12):1472-1477(2020)
[1]李雪靖,张慧玲,王晓丽,高胜男,刘洋,刘国强.芪参益气滴丸治疗慢性心力衰竭的循证药物经济学评价[J].中国医院用药评价与分析,2020,20(12):1472-1477+1482. DOI： 10.14009/j.issn.1672-2124.2020.12.017.

LI Xuejing, ZHANG Huiling, WANG Xiaoli, et al. Evidence-Based Pharmacoeconomic Evaluation of Qishen Yiqi Dripping Pills in the Treatment of Chronic Heart Failure. [J]. 20(12):1472-1477(2020) DOI： 10.14009/j.issn.1672-2124.2020.12.017.

摘要

目的:基于循证证据

综合评价芪参益气滴丸治疗慢性心力衰竭的安全性、有效性和经济性

为临床治疗提供循证药物经济学依据。方法:计算机检索PubMed数据库、EMBase数据库、Cochrane图书馆、Clinical trials. gov、中国期刊全文数据库、维普中文科技期刊全文数据库和万方医学数据库

收集芪参益气滴丸（研究组

在常规抗心力衰竭治疗方案基础上联合应用芪参益气滴丸）对比常规抗心力衰竭药（对照组

常规抗心力衰竭治疗）治疗慢性心力衰竭的随机对照试验

筛选文献、提取资料后

采用Review Manager 5.3软件进行荟萃分析（Meta分析）

最后结合有效性、安全性和经济性进行药物经济学评价。结果:纳入27篇文献

合计3 893例患者。Meta分析结果显示

研究组患者心功能改善总有效率显著高于对照组

差异有统计学意义（RR=1.20

95%CI=1.16～1.23

P<0.000 01）;与对照组相比

研究组治疗方案可显著改善患者的左心室射血分数（MD=6.79

95%CI=6.50～7.07

P<0.000 01）、6 min步行距离（MD=45.08

95%CI=43.09～47.08

P<0.000 01）和血脑钠肽含量（MD=-108.51

95%CI=-112.54～-104.49

P<0.000 01）

差异均有统计学意义;两组患者不良反应（肝肾功能异常、恶心及干咳）发生率的差异均无统计学意义（P>0.05）。成本-效果分析显示

增量成本-效果比为2 503.03。结论:与常规抗心力衰竭药比较

芪参益气滴丸可显著提高慢性心力衰竭患者的有效率、左心室射血分数、6 min步行距离和血脑钠肽含量

每增加1个效果需要多花费2 503.03元

在临床治疗中可根据患者自身支付意愿选择治疗方案。

Abstract

OBJECTIVE:To comprehensively evaluate the safety

efficacy and economy of Qishen Yiqi dropping pills in the treatment of chronic heart failure based on evidence-based evidence

so as to provide evidence-based pharmacoeconomics basis for clinical treatment.METHODS:PubMed

EMBase

the Cochrane library

Clinical trials.gov

CNKI

VIP database and Wanfang database were retrieved to collect randomized controlled trials（RCT） of Qishen Yiqi dropping pills（the research group was given Qishen Yiqi dropping pills on the basis of routine anti-heart failure treatment） and conventional anti-heart failure drugs（the control group received conventional anti-heart failure therapy） in the treatment of chronic heart failure.After literature screening and data extraction

Review Manager 5.3 software was used for Meta-analysis.Pharmacoeconomic evaluation was performed with efficacy

safety and economy.RESULTS:Totally 27 literature was collected

including 3 893 patients.Meta-analysis results showed that the total effective rate of improvement of cardiac function in the research group was significantly higher than that in the control group

and the difference was statistically significant（RR=1.20

95%CI=1.16-1.23

P<0.000 01）.Compared with the control group

the treatment regimen of the research group can significantly improve patients’left ventricular ejection fraction（MD=6.79

95% CI=6.50-7.07

P <0·000 01）

6 min walking distance（MD=45.08

95% CI=43.09-47.08

P<0.000 01） and brain natriuretic peptide content（MD=-108.51

95% CI=-112.54--104.49

P<0.000 01）

the difference was statistically significant.The incidence of adverse drug reactions（abnormal liver and kidney function

nausea and cough） was not significantly different between two groups（P>0.05）.Cost-effectiveness analysis showed that the incremental cost-effectiveness ratio was 2 503.03.CONCLUSIONS:Compared with conventional anti-heart failure drugs

Qishen Yiqi dropping pills can significantly improve the effective rate

left ventricular ebitus fraction

6 min walking distance and the content of blood brain natriuretic peptide in patients with chronic heart failure.Each additional effect will cost more 2 503.03 yuan

the treatment regimen can be selected according to patients ’own willingness to pay in clinical treatment.

关键词

芪参益气滴丸慢性心力衰竭Meta分析药物经济学评价

Keywords

Qishen Yiqi dropping pillsCoronary heart diseaseMeta-analysisPharmacoeconomic evaluation

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