Effects of Quyou Decoction Combined with Photodynamic Therapy on the Degree of Skin Lesion,Quality of Life and Recurrence in Patients with Intractable Plantar Warts of Damp-Heat and Blood Stasis Type

JING Weifang; ZHOU Nana; QIU Sisi; SUN Yan

doi:10.14009/j.issn.1672-2124.2020.12.011

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Effects of Quyou Decoction Combined with Photodynamic Therapy on the Degree of Skin Lesion,Quality of Life and Recurrence in Patients with Intractable Plantar Warts of Damp-Heat and Blood Stasis Type

更新时间：2022-10-08

- Effects of Quyou Decoction Combined with Photodynamic Therapy on the Degree of Skin Lesion,Quality of Life and Recurrence in Patients with Intractable Plantar Warts of Damp-Heat and Blood Stasis Type
- Vol. 20, Issue 12, Pages: 1449-1452(2020)
- 作者机构：
  
  1. 河北中石油中心医院皮肤科
  2. 廊坊市人民医院皮肤科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.12.011
  CLC： R752.5
- Published：2020，
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[1]景伟芳,周娜娜,邱思思,孙焱.祛疣汤联合光动力治疗对湿热血瘀型顽固性跖疣患者皮损程度、生活质量及复发情况的影响[J].中国医院用药评价与分析,2020,20(12):1449-1452.

JING Weifang, ZHOU Nana, QIU Sisi, et al. Effects of Quyou Decoction Combined with Photodynamic Therapy on the Degree of Skin Lesion,Quality of Life and Recurrence in Patients with Intractable Plantar Warts of Damp-Heat and Blood Stasis Type. [J]. 20(12):1449-1452(2020)
[1]景伟芳,周娜娜,邱思思,孙焱.祛疣汤联合光动力治疗对湿热血瘀型顽固性跖疣患者皮损程度、生活质量及复发情况的影响[J].中国医院用药评价与分析,2020,20(12):1449-1452. DOI： 10.14009/j.issn.1672-2124.2020.12.011.

JING Weifang, ZHOU Nana, QIU Sisi, et al. Effects of Quyou Decoction Combined with Photodynamic Therapy on the Degree of Skin Lesion,Quality of Life and Recurrence in Patients with Intractable Plantar Warts of Damp-Heat and Blood Stasis Type. [J]. 20(12):1449-1452(2020) DOI： 10.14009/j.issn.1672-2124.2020.12.011.

摘要

目的:探讨祛疣汤联合光动力治疗对湿热血瘀型顽固性跖疣患者皮损程度、生活质量及复发情况的影响。方法:将2018年3月至2019年6月河北中石油中心医院和廊坊市人民医院皮肤科接诊的100例湿热血瘀型顽固性跖疣患者按照随机数字表法分为对照组和观察组

每组50例。对照组患者给予光动力治疗

并外用维A酸乳膏;观察组患者给予光动力治疗联合祛疣汤浸泡治疗。观察两组患者的临床疗效、皮损改善情况、生活质量、T细胞亚群及复发情况。结果:观察组患者的总有效率为92.00%（46/50）

较对照组的74.00%（37/50）明显更高

差异有统计学意义（P

0.05）;治疗后

两组患者皮损各项评分及皮肤病生活质量指数总分与治疗前相比明显降低

且观察组患者与对照组相比明显更低

差异均有统计学意义（P

0.05）。治疗后

两组患者CD3

、CD4

及CD4

/CD8

水平与治疗前相比明显升高

观察组患者与对照组相比明显更高

差异均有统计学意义（P

0.05）;而两组患者CD8

水平与治疗前比较的差异均无统计学意义（P

0.05）。观察组患者的复发率为4.00%（2/50）

较对照组的18.00%（9/50）明显更低

差异有统计学意义（P

0.05）。结论:对湿热血瘀型顽固性跖疣患者实施祛疣汤联合光动力治疗

其疗效优于光动力联合维A酸乳膏治疗

可有效促进患者皮损消退

明显改善患者的生活质量和细胞免疫功能

且能够显著降低复发的风险。

Abstract

OBJECTIVE:To probe into the effect of Quyou decotion combined with photodynamic therapy on the degree of skin lesion

quality of life and recurrence in patients with intractable plantar warts of damp-heat and blood stasis type.METHODS:Totally 100 patients with intractable plantar warts of damp-heat and blood stasis type admitted into Hebei Petro China Central Hospital and Langfang People’s Hospital from Mar.2018 to Jun.2019 were selected and divided into control group and observation group via random number table

with 50 cases in each group.The control group was given photodynamic therapy combined with tretinoin cream for external use;while the observation group was given photodynamic’therapy combined Quyou decoction for soaking.The clinical efficacy

improvements of skin lesion

quality of life

T cell subset and recurrence of both groups were observed.RESULTS:The total effective rate of observation group was 92.00%（46/50）

which was significantly higher than that of the control group（74.00%

37/50）

with statistically significant difference（P

0.05）;after treatment

the various scores of skin lesion and the total scores of QOL indicator of the two groups were significantly lower than those of before treatment

and those of the observation group were significantly lower than the control group

with statistically significant differences（P

0.05）.After treatment

the CD3

CD4

and CD4

/CD8

levels of both groups were significantly higher than those of before treatment

and those of the observation group were significantly higher than the control group

with statistically significant differences（P

0.05）;while there was no statistical significance in difference in CD8

levels between two groups before and after treatment（P

0.05）.The recurrence rate of observation group was4.00%（2/50）

which was significantly lower than that of the control group（18.00%

9/50）

with statistically significant difference（P

0.05）.CONCLUSIONS:For patients with intractable plantar warts of damp-heat and blood stasis type

Quyou decoction combined with photodynamic therapy is more effective than photodynamic therapy combined with tretinoin cream

which can effectively promote the regression of skin lesions

significantly improve their quality of life and cellular immune function

and significantly reduce the risk of recurrence.

关键词

光动力祛疣汤顽固性跖疣皮损程度生活质量

Keywords

Photodynamic therapyQuyou decoctionIntractable plantar wartsDegree of skin lesionQuality of life

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