Discussion on Network Pharmacology of Shenling Baizhu Powder in the Treatment of COVID-19 in Recovery Phase

LIN Tong; LI Li; LIANG Caijun; ZENG Hui; LI Xiaoliang; PENG Lisheng

doi:10.14009/j.issn.1672-2124.2020.12.007

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Discussion on Network Pharmacology of Shenling Baizhu Powder in the Treatment of COVID-19 in Recovery Phase

更新时间：2022-10-08

- Discussion on Network Pharmacology of Shenling Baizhu Powder in the Treatment of COVID-19 in Recovery Phase
- Vol. 20, Issue 12, Pages: 1433-1436(2020)
- 作者机构：
  
  1. 广州中医药大学第四临床医学院
  2. 深圳市第三人民医院心内科
  3. 深圳市中医院科教科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.12.007
  CLC： R285
- Published：2020，
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[1]林彤,李丽,梁彩君,曾辉,李晓良,彭立生.参苓白术散治疗新型冠状病毒肺炎恢复期的网络药理学探讨[J].中国医院用药评价与分析,2020,20(12):1433-1436+1441.

LIN Tong, LI Li, LIANG Caijun, et al. Discussion on Network Pharmacology of Shenling Baizhu Powder in the Treatment of COVID-19 in Recovery Phase. [J]. 20(12):1433-1436(2020)
[1]林彤,李丽,梁彩君,曾辉,李晓良,彭立生.参苓白术散治疗新型冠状病毒肺炎恢复期的网络药理学探讨[J].中国医院用药评价与分析,2020,20(12):1433-1436+1441. DOI： 10.14009/j.issn.1672-2124.2020.12.007.

LIN Tong, LI Li, LIANG Caijun, et al. Discussion on Network Pharmacology of Shenling Baizhu Powder in the Treatment of COVID-19 in Recovery Phase. [J]. 20(12):1433-1436(2020) DOI： 10.14009/j.issn.1672-2124.2020.12.007.

摘要

目的:探讨参苓白术散治疗新型冠状病毒肺炎（COVID-19）恢复期肺脾气虚证的潜在作用机制及可行性。方法:使用中药数据库筛选参苓白术散的活性成分并预测靶点;运用Cytoscape构建和分析网络;通过靶点间蛋白质相互作用网络提取重要靶点;对重要靶点行生物功能及通路进行富集分析;用iGEMDOCK进行分子对接实验。结果:纳入127种参苓白术散所含活性成分

预测到193个靶点

核心成分为二氢槲皮素、山柰酚和木犀草素等。26个重要靶点富集在免疫炎症反应（白细胞介素17、B细胞及肿瘤坏死因子等通路）、血管紧张素对循环系统的调节和肾上腺素能等神经-内分泌相关功能。5个核心成分具有与COVID-19靶点结合的潜能。结论:参苓白术散可能通过作用于免疫炎症反应、循环及神经-内分泌相关信号通路

结合调理肠道菌群

从而治疗COVID-19恢复期肺脾气虚证。

Abstract

OBJECTIVE:To probe into the potential mechanism and feasibility of Shenling Baizhu powder in the treatment of Qi-deficiency of lung and spleen of COVID-19 in recovery phase.METHODS:Use the Chinese medicine database to screen the active ingredients of Shenling Baizhu powder and predict the targets;use Cytoscape to construct and analyze the network;to extract important targets through the protein interaction network among targets;to perform biological function and pathway enrichment analyses on important targets;and to conduct molecular docking experiment through iGEMDOCK.RESULTS:Totally 127 kinds of active ingredients were contained in Shenling Baizhu powder

193 targets were predicted

and the core ingredients were dihydroquercetin

kaempferol and luteolin.26 important targets were enriched in neuro-endocrine related functions including immune-inflammatory response（pathways of interleukin 17

B cells and tumor necrosis factor）

regulation of angiotensin on circulatory system

and adrenergic.Of which 5 core ingredients had the potential to bind to COVID-19 targets.CONCLUSIONS:Shenling Baizhu powder may act on the immune-inflammatory response

circulation and neuro-endocrine related signal pathways

combined with regulating the intestinal flora

so as to treat the Qi-deficiency of lung and spleen of COVID-19 in recovery phase.

关键词

新型冠状病毒肺炎参苓白术散网络药理学分子对接

Keywords

COVID-19Shenling Baizhu powderNetwork pharmacologyMolecular docking

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