OBJECTIVE:To probe into the effects of Kushen decoction combined with moisture exposed burn ointment（MEBO） on traditional Chinese medicine（TCM） syndrome integral and anal edema score in patients with acute anal fissure.METHODS:Totally 114 patients with acute anal fissure admitted into Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University from May 2018 to Oct.2019 were selected and divided into observation group and control group via random number table

with 57 cases in each group.The control group was treated with MEBO alone

while the observation group was given Kushen decoction based on the observation group.The clinical efficacy of two groups were observed

differences in TCM syndrome integral

remission time of symptoms and anal edema score were compared between two groups.RESULTS:The total effective rate of observation group was 94.74%（54/57）

which was significantly higher than that of the control group（80.70%

46/57）

with statistically significant difference（P<0.05）.After treatment

the primary symptom score

secondary symptom score and total score of TCM syndrome integral of both groups were significantly lower than those of before treatment

and those of the observation group were significantly lower than the control group

with statistically significant differences（P<0.05）.The remission time of pain and constipation

disappearance time of hemorrhage and recovery time of anal fissure of observation group were significantly shorter than those of the control group

with statistically significant differences（P<0.05）.After treatment

the anal edema scores of both groups were significantly lower than those of before treatment

and that of the observationgroup was significantly lower than the control group

with statistically significant differences（P<0.05）.CONCLUSIONS:The application of Kushen decoction combined with MEBO in the treatment of acute anal fissure can significantly reduce TCM syndrome integral

promote rapid relief of various clinical symptoms

alleviate anal edema

and the effect is worthy of recognition.