Progress of Gene Polymorphism and Clinical Application of Warfarin

WANG Weili; SONG Cangsang; ZHANG Yang; SONG Wenbin; MAO Panpan

doi:10.14009/j.issn.1672-2124.2020.11.029

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Progress of Gene Polymorphism and Clinical Application of Warfarin

更新时间：2022-10-08

- Progress of Gene Polymorphism and Clinical Application of Warfarin
- Vol. 20, Issue 11, Pages: 1398-1401(2020)
- 作者机构：
  
  1. 昆明市第一人民医院药学部
  2. 大理大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.11.029
  CLC： R973.2
- Published：2020，
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[1]王威丽,宋沧桑,张阳,宋文彬,毛盼盼.华法林的基因多态性研究和临床应用进展[J].中国医院用药评价与分析,2020,20(11):1398-1401+1405.

WANG Weili, SONG Cangsang, ZHANG Yang, et al. Progress of Gene Polymorphism and Clinical Application of Warfarin. [J]. 20(11):1398-1401(2020)
[1]王威丽,宋沧桑,张阳,宋文彬,毛盼盼.华法林的基因多态性研究和临床应用进展[J].中国医院用药评价与分析,2020,20(11):1398-1401+1405. DOI： 10.14009/j.issn.1672-2124.2020.11.029.

WANG Weili, SONG Cangsang, ZHANG Yang, et al. Progress of Gene Polymorphism and Clinical Application of Warfarin. [J]. 20(11):1398-1401(2020) DOI： 10.14009/j.issn.1672-2124.2020.11.029.

摘要

华法林是临床上常用的抗凝血药之一

其疗效与诸多因素有关

这些因素限制了该药在临床上的进一步使用。采用药物基因组学来解释华法林抗凝作用的有效性及安全性成为了目前研究的新兴领域。本文就华法林相关基因多态性及其临床应用进展等方面进行了详细的阐述

以期为今后华法林的个体化抗凝治疗提供理论基础。

Abstract

Warfarin is one of the commonly used anticoagulant drugs in clinical practice. Its efficacy is related to many factors

which limit its further use in clinical practice. The use of pharmacogenomics to explain the efficacy and safety of warfarin anticoagulant has become an emerging field of current research. Therefore

in this thesis

Warfarin related gene polymorphism and clinical application are described in detail in order to provide the theoretical basis for the individualized anticoagulation therapy of Warfarin in the future.

关键词

华法林基因多态性临床应用个体化治疗

Keywords

WarfarinGene polymorphismClinical applicationIndividualized treatment

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