Analysis of 405 Cases of Adverse Drug Reactions Induced by Yanhuning Injection in Xi’an from 2014 to 2019

ZHANG Hongli; HUANG Jing; WANG Jingjing; YE Dan; YAN Kangkang; WU Tingting

doi:10.14009/j.issn.1672-2124.2020.11.028

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Analysis of 405 Cases of Adverse Drug Reactions Induced by Yanhuning Injection in Xi’an from 2014 to 2019

更新时间：2022-10-08

- Analysis of 405 Cases of Adverse Drug Reactions Induced by Yanhuning Injection in Xi’an from 2014 to 2019
- Vol. 20, Issue 11, Pages: 1395-1397(2020)
- 作者机构：
  
  1. 西安市中心医院药剂科
  2. 西安市第三医院药剂科
  3. 西安市食品药品检验所药品不良反应监测中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.11.028
  CLC： R95
- Published：2020，
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[1]张宏丽,黄婧,王晶晶,叶丹,闫抗抗,吴婷婷.2014—2019年西安市405例炎琥宁注射液致药品不良反应报告分析[J].中国医院用药评价与分析,2020,20(11):1395-1397.

ZHANG Hongli, HUANG Jing, WANG Jingjing, et al. Analysis of 405 Cases of Adverse Drug Reactions Induced by Yanhuning Injection in Xi’an from 2014 to 2019. [J]. 20(11):1395-1397(2020)
[1]张宏丽,黄婧,王晶晶,叶丹,闫抗抗,吴婷婷.2014—2019年西安市405例炎琥宁注射液致药品不良反应报告分析[J].中国医院用药评价与分析,2020,20(11):1395-1397. DOI： 10.14009/j.issn.1672-2124.2020.11.028.

ZHANG Hongli, HUANG Jing, WANG Jingjing, et al. Analysis of 405 Cases of Adverse Drug Reactions Induced by Yanhuning Injection in Xi’an from 2014 to 2019. [J]. 20(11):1395-1397(2020) DOI： 10.14009/j.issn.1672-2124.2020.11.028.

摘要

目的:探讨炎琥宁注射液引发药品不良反应（adverse drug reaction

ADR）的一般特点和规律

为临床合理用药提供参考。方法:采用回顾性分析方法

对2014—2019年西安市ADR监测中心数据库收集的405例炎琥宁注射液致ADR报告进行统计分析。结果:405使用炎琥宁注射液发生ADR的患者中

<10岁患者所占比例最高

为49.14%（199例）; 313例患者（占77.28%）出现皮肤及其附件损害

主要临床表现为不同程度的皮疹、瘙痒症和荨麻疹

此外

全身性反应、给药部位反应和胃肠道反应也是常见ADR

与药品说明书中的描述有较大出入;对231例患者（占57.04%）的ADR采取了治疗措施; 242例患者（占59.75%）的ADR结果为痊愈。结论:药品生产厂家应加强对炎琥宁注射液的ADR监测

及时更新药品说明书。临床应加强对炎琥宁注射液致ADR的预防和监测

以确保患者用药安全。

Abstract

OBJECTIVE: To probe into the general characteristics and regularities of adverse drug reactions（ ADR） induced by Yanhuning injection

so as to provide reference for clinical rational drug use. METHODS:Retrospective analysis method was used to analyze 405 ADR reports collected by Xi’an Adverse Drug Reaction Monitoring Center database from 2014 to 2019. RESULTS: Among the 405 patients with ADR induced by Yanhuning injection

the proportion of patients < 10 years old was the highest

which was 49. 14%（ 199 cases）. Totally 313 patients（ 77. 28%） had skin and appendage damage

the main clinical manifestations were rash

pruritus and urticaria in varying degrees. In addition

systemic reaction

administration site reaction and gastrointestinal reaction were common ADR

which were quite different from the description in the drug instructions. Treatment measures were taken for 231 patients（ 57. 04%） with ADR. ADR in 242 patients（ 59. 75%） were resolved. CONCLUSIONS: Drug manufacturers should strengthen ADR monitoring of Yanhuning injection and update the drug instructions in time. The prevention and monitoring of ADR induced by Yanhuning injection should be strengthened clinically to ensure the safety of medication for patients.

关键词

炎琥宁注射液药品不良反应药物警戒药品安全

Keywords

Yanhuning injectionAdverse drug reactionsPharmacovigilanceMedication safety

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