Systematic Review of Efficacy and Safety of Palonosetron in the Prevention of Postoperative Nausea and Vomiting

WANG Peng; YI Hong; LI Xue; LIN Yong

doi:10.14009/j.issn.1672-2124.2020.11.021

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Systematic Review of Efficacy and Safety of Palonosetron in the Prevention of Postoperative Nausea and Vomiting

更新时间：2022-10-08

- Systematic Review of Efficacy and Safety of Palonosetron in the Prevention of Postoperative Nausea and Vomiting
- Vol. 20, Issue 11, Pages: 1365-1369(2020)
- 作者机构：
  
  成都医学院第二附属医院/核工业四一六医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.11.021
  CLC： R614
- Published：2020，
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[1]王鹏,易红,李雪,林勇.帕洛诺司琼预防术后恶心呕吐的有效性与安全性的系统评价[J].中国医院用药评价与分析,2020,20(11):1365-1369+1373.

WANG Peng, YI Hong, LI Xue, et al. Systematic Review of Efficacy and Safety of Palonosetron in the Prevention of Postoperative Nausea and Vomiting. [J]. 20(11):1365-1369(2020)
[1]王鹏,易红,李雪,林勇.帕洛诺司琼预防术后恶心呕吐的有效性与安全性的系统评价[J].中国医院用药评价与分析,2020,20(11):1365-1369+1373. DOI： 10.14009/j.issn.1672-2124.2020.11.021.

WANG Peng, YI Hong, LI Xue, et al. Systematic Review of Efficacy and Safety of Palonosetron in the Prevention of Postoperative Nausea and Vomiting. [J]. 20(11):1365-1369(2020) DOI： 10.14009/j.issn.1672-2124.2020.11.021.

摘要

目的:对帕洛诺司琼预防术后恶心呕吐的有效性与安全性进行系统评价。方法:计算机检索Pub Med、the Cochrane Library及EMBase等英文数据库

中国期刊全文数据库、万方数据库及维普中文期刊全文数据库等中文数据库

纳入帕洛诺司琼预防术后恶心呕吐的随机对照试验[观察组患者予以帕洛诺司琼

按给药剂量分为观察1组（0.050 mg）、观察2组（0.075 mg）;对照组患者给于昂丹司琼8 mg（昂丹司琼对照组）或安慰剂（安慰剂对照组）]

采用R i386（version 3.3.1）软件对所纳入文献进行荟萃分析（Meta分析）。结果:共纳入17篇文献。Meta分析显示

术后24 h内

观察2组与昂丹司琼对照组患者完全缓解率的差异无统计学意义（RR=1.35

95%CI=0.87～2.09

P=0.180 0）;术后24、72 h内

观察2组患者的完全缓解率明显优于安慰剂对照组（RR=1.56

95%CI=1.16～1.29

P <0.000 1; RR=1.52

95%CI=1.34～1.72

P <0.000 1）;术后24 h内

观察2组患者的完全缓解率明显优于观察1组（RR=0.85

95%CI=0.72～0.99

P=0.043 2）。观察组、对照组患者不良反应发生率的差异无统计学意义（P> 0.05）。结论:帕洛诺司琼能有效预防术后恶心呕吐

具有良好的安全性。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of palonosetron in the prevention of postoperative nausea and vomiting. METHODS: Pub Med

the Cochrane Library

EMBase

CNKI

Wanfang database and VIP database were retrieved for the randomized controlled trials of palonosetron in the prevention of postoperative nausea and vomiting [patients in the observation group were given palonosetron

and were divided into the observation group 1（ 0. 050 mg） and the observation group 2（ 0. 075 mg） according to the administration dose; patients in the control group were given ondansetron 8 mg（ ondansetron control group） or placebo（ placebo control group） ]. Meta-analysis of the included literature was performed by using R i386（ version 3. 3. 1） software. RESULTS: A total of 17 literature were collected. Meta-analysis showed that within 24 h after surgery

there was no significant difference in the complete remission rate between the observation group 2 and the ondansetron control group（ RR = 1. 35

95% CI = 0. 87-2. 09

P =0. 180 0）. Within 24 and 72 h after surgery

the complete remission rate of the observation group 2 was significantly better than that of the placebo control group（ RR = 1. 56

95% CI = 1. 16-1. 29

P < 0. 000 1; RR = 1. 52

95% CI = 1. 34-1. 72

P < 0. 000 1）. Within 24 h after surgery

the complete remission rate of the observation group 2 was significantly better than that of the observation group 1（ RR = 0. 85

95% CI = 0. 72-0. 99

P = 0. 043 2）. There was no significant difference in the incidence of adverse drug reactions between the observation group and the control group（ P > 0. 05）. CONCLUSIONS: Palonosetron can effectively prevent postoperative nausea and vomiting and has higher safety.

关键词

帕洛诺司琼昂丹司琼安慰剂术后恶心呕吐Meta分析

Keywords

PalonosetronOndansetronPlaceboPostoperative nausea and vomitingMeta-analysis

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