OBJECTIVE: To compare the efficacy between Flunarizine hydrochloride capsule and Anisodine hydrobromide tablets in the treatment of vestibular migraine and their effects on anxiety and depression. METHODS: A total of 121 patients with vestibular migraine admitted into the First Affiliated Hospital of Xinxiang Medical College from Jun. 2018 to Dec. 2019 were selected and divided into control group（ 61 cases） and observation group（ 60 cases）

via the random number table. The control group was treated with Flunarizine hydrochloride capsule and the observation group was treated with Anisodine hydrobromide tablets

both groups were treated continuously for4 weeks. Differences in dizziness handicap inventory（ DHI） including physical（ P）

emotional（ E） and functional（ F） scores

self-rating anxiety scale（ SAS） and self-rating depression rating depression scale（ SDS） were compared between two groups before treatment

4 weeks after treatment and during follow-up; recurrence of dizziness during follow-up and incidence of adverse drug reactions during treatment of the two groups were recorded. RESULTS: Scores of DHI and its subitems

SAS and SDS of both groups after 4 weeks of treatment were significantly lower than those of before treatment

the above scores during follow-up were significantly lower than those after 4 weeks of treatment

the DHI score

E score

SAS and SDS scores of the observation group after 4 weeks of treatment and during follow-up were significantly lower than those of the control group

with statistically significant differences（ P < 0. 05）; there was no statistical significance in difference in F and P scores between two groups after 4 weeks of treatment and during followup（ P > 0. 05）. During follow-up

the cumulative frequency of dizziness attack of observation group was significantly less than that of the control group

the cumulative time of dizziness attack was significantly shorter than that of the control group

the cumulative severity of dizziness was significantly lower than that of the control group

with statistically significant differences（ P < 0. 05）. During treatment

the incidences of adverse drug reactions of the control group and observation group were respectively 4. 92%（ 3/61） and 5. 00%（ 3/60）

and the difference has no statistical significance（ P > 0. 05）. CONCLUSIONS: Anisodine hydrobromide tablets are more effective than flunarizine hydrochloride capsules in improving the symptoms of vestibular migraine and preventing recurrence

especially in reducing anxiety and depression

with high safety.