Mechanism of Shengjiang Xiexin Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology

CHEN Xi; YANG Ting; ZHANG Congen; YU Xiaohong; ZHAO Kuijun; MA Zhijie

doi:10.14009/j.issn.1672-2124.2020.11.003

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Mechanism of Shengjiang Xiexin Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology

更新时间：2022-10-08

- Mechanism of Shengjiang Xiexin Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology
- Vol. 20, Issue 11, Pages: 1290-1294(2020)
- 作者机构：
  
  1. 首都医科大学附属北京友谊医院中药剂科
  2. 山西医科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.11.003
  CLC： R285
- Published：2020，
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[1]陈熹,杨婷,章从恩,于小红,赵奎君,马致洁.基于网络药理学的生姜泻心汤治疗结直肠癌的作用机制研究[J].中国医院用药评价与分析,2020,20(11):1290-1294+1299.

CHEN Xi, YANG Ting, ZHANG Congen, et al. Mechanism of Shengjiang Xiexin Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology. [J]. 20(11):1290-1294(2020)
[1]陈熹,杨婷,章从恩,于小红,赵奎君,马致洁.基于网络药理学的生姜泻心汤治疗结直肠癌的作用机制研究[J].中国医院用药评价与分析,2020,20(11):1290-1294+1299. DOI： 10.14009/j.issn.1672-2124.2020.11.003.

CHEN Xi, YANG Ting, ZHANG Congen, et al. Mechanism of Shengjiang Xiexin Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology. [J]. 20(11):1290-1294(2020) DOI： 10.14009/j.issn.1672-2124.2020.11.003.

摘要

目的:基于网络药理学方法

探讨生姜泻心汤治疗结直肠癌（colorectal cancer

CRC）的药理作用机制

为经典方剂拓展应用及药物机制研究提供依据。方法:通过中药系统药理学技术平台获取生姜泻心汤主要化学成分及其作用靶点

借助OMIM数据库、TTD数据库和Gene Cards数据库获取CRC疾病靶点

利用STRING平台进行蛋白质相互作用分析

构建PPI网络图

运用Metascape平台对"药物-成分-靶点"及生物过程、信号通路进行统计分析

最后采用Cytoscape软件构建"生姜泻心汤成分-结直肠癌靶点-通路"网络。结果:生姜泻心汤治疗CRC的核心活性成分为黄芩素、柚皮素、刺芒柄花素及1-甲氧基菜豆素等;核心靶点有HSP90AA1、ESR1、AR及NOS2等;调控的信号通路主要有恶性肿瘤相关通路、CRC相关通路、白细胞介素17信号通路、内分泌耐药通路及细胞凋亡通路等;其功能主要为调节转录因子结合、核受体活性、转录因子活性、类固醇激素受体活性及蛋白激酶结合等。结论:本研究初步验证了生姜泻心汤治疗CRC的作用机制

并为生姜泻心汤的临床应用及机制研究提供了理论基础。

Abstract

OBJECTIVE: Based on the method of network pharmacology

to explore the pharmacological mechanism of Shengjiang Xiexin decoction in the treatment of colorectal cancer（ CRC）

so as to provided a basis for the application of classic prescription expansion and drug mechanisms research. METHODS: The main chemical components and targets of Shengjiang Xiexin decoction were obtained through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（ TCMSP）. CRC disease targets were collected by OMIM database

TTD database and GeneCards database. The protein-protein interaction（ PPI） analysis and PPI network diagram were performed by STRING platform. Metascape platform was used to conduct statistical analysis on "drugscomponents-targets"

biological processes and pathways. Finally

the Cytoscape software was adopted to establish the network of"ingredients of Shengjiang Xiexin decoction-colorectal cancer-pathway". RESULTS: The core active ingredients of Shengjiang Xiexin decoction in the treatment of CRC were baicalein

naringenin

formononetin

1-Methoxy-phaseollidin

etc; the core targets were HSP90 AA1

ESR1

NOS2

etc; the main participated pathways were cancer-related pathway

CRC-related pathway

IL-17 signaling pathway

endocrine resistance pathway

apoptosis pathway

etc; the functions of Shengjiang Xiexin decoction were mainly to regulate transcription factor binding

nuclear receptor activity

transcription factor activity

steroid hormone receptor activity

protein kinase binding

etc. CONCLUSIONS: This study has preliminarily verified the action mechanism of Shengjiang Xiexin decoction in the treatment of CRC

and provided theoretical basis for its clinical application and mechanism research.

关键词

生姜泻心汤结直肠癌网络药理学靶点预测

Keywords

Shengjiang Xiexin decoctionColorectal cancerNetwork pharmacologyTargets prediction

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