OBJECTIVE: To probe into the risk factors of antibiotic-associated diarrhea（ AAD） in intensive care unit（ ICU） patients in the First Affiliated Hospital of China Medical University（ hereinafter referred to as "our hospital"）

so as to provide evidence for formulating effective prevention and control measures. METHODS: Clinical data of 30 ADD patients（ ADD group） in ICU（ Surgical ICU

Neurological ICU

Respiratory ICU

Cycle ICU and Emergency ICU） in our hospital from Jan. 2018 to Jan. 2019 were retrospectively analyzed

another 120 patients without antibiotic-related diarrhea during the same period were randomly selected as the control group（ non-AAD group）

univariate and logistic regression analysis were performed. RESULTS: The incidence of AAD in ICU patients in our hospital was related to the application time（ t = 6. 171

P < 0. 05）

category（ t = 3. 951

P < 0. 05） of antibiotics and whether used in drug combination; the incidence of AAD in patients with three and above drug combination of antibiotics was obvious higher than that of antibiotics alone

with statistically significant difference（ χ2= 4. 327

P < 0. 05）; the application time of antibiotics（ P = 0. 034）

the application of fluoroquinolones（ P =0. 000） and β-lactamase inhibitor（ P = 0. 004） were the significant risk factors of AAD in ICU patients.CONCLUSIONS: Strictly grasp the indications for the application of antibiotics

under the precondition of ensuring effective treatment

shorten the time of medication as much as possible

choose antibiotics with low probability of inducing AAD

choose narrow-spectrum antibiotics

avoid unnecessary drug combination and avoid frequent replacement of antibiotic are the important measures to avoid AAD in ICU patients