Retrospectively Analysis on Adverse Drug Reactions Induced by Drug Combination of Antiviral Agents in 7 Patients with COVID-19

TANG Cai ’e; KONG Jianjian; TUO Mingfu; YANG Kun; SHEN Yabing

doi:10.14009/j.issn.1672-2124.2020.10.030

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Retrospectively Analysis on Adverse Drug Reactions Induced by Drug Combination of Antiviral Agents in 7 Patients with COVID-19

更新时间：2022-10-08

- Retrospectively Analysis on Adverse Drug Reactions Induced by Drug Combination of Antiviral Agents in 7 Patients with COVID-19
- Vol. 20, Issue 10, Pages: 1270-1272(2020)
- 作者机构：
  
  甘肃医学院附属医院临床药学室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.10.030
  CLC： R969.3
- Published：2020，
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[1]唐彩娥,孔健健,脱鸣富,杨鲲,沈亚兵.7例新型冠状病毒肺炎患者联合应用抗病毒药致药品不良反应的回顾性分析[J].中国医院用药评价与分析,2020,20(10):1270-1272.

TANG Cai ’e, KONG Jianjian, TUO Mingfu, et al. Retrospectively Analysis on Adverse Drug Reactions Induced by Drug Combination of Antiviral Agents in 7 Patients with COVID-19. [J]. 20(10):1270-1272(2020)
[1]唐彩娥,孔健健,脱鸣富,杨鲲,沈亚兵.7例新型冠状病毒肺炎患者联合应用抗病毒药致药品不良反应的回顾性分析[J].中国医院用药评价与分析,2020,20(10):1270-1272. DOI： 10.14009/j.issn.1672-2124.2020.10.030.

TANG Cai ’e, KONG Jianjian, TUO Mingfu, et al. Retrospectively Analysis on Adverse Drug Reactions Induced by Drug Combination of Antiviral Agents in 7 Patients with COVID-19. [J]. 20(10):1270-1272(2020) DOI： 10.14009/j.issn.1672-2124.2020.10.030.

摘要

目的:探讨新型冠状病毒肺炎（COVID-19）患者联合应用抗病毒药（利巴韦林注射液+洛匹那韦利托那韦片+重组人干扰素α2b注射液）致药品不良反应（adverse drug reaction

ADR）的发生特点及规律

为临床合理用药提供参考。方法:采用回顾性分析方法

对甘肃医学院附属医院收治的7例COVID-19患者在抗病毒药联合治疗过程中出现的ADR进行统计分析。结果:7例COVID-19患者中

6例出现胆红素升高

5例出现腹泻

4例出现食欲减退

1例出现轻度肝功能异常

1例出现头晕。胆红素升高、食欲减退、轻度肝功能异常和头晕等症状在停用抗病毒药后逐渐消失

3例重症腹泻患者予以双歧杆菌三联活菌肠溶胶囊后症状逐渐好转。胆红素升高平均出现时间为用药（3. 50±1. 05） d后

腹泻出现时间均为用药2 d后。结论:医疗机构的临床药师和医师应更多关注和总结合理用药的相关内容

为国家修订《新型冠状病毒肺炎诊疗方案》提供参考。

Abstract

OBJECTIVE: To probe into the characteristics and regularities of adverse drug reactions（ ADR） induced by drug combination of antiviral agents（ ribavirin injection + Lopinavir/Ritonavir tablets + recombinant human interferonα2 b injection） in patients with COVID-19

so as to promote rational medication. METHODS: Retrospective analysis was adopted to collect and analyze the ADR occurred during the treatment of drug combination of antiviral agents in 7 patients with COVID admitted into the Affiliated Hospital of Gansu Medical College. RESULTS: Of the 7 patients with COVID-19

6 had bilirubin increase

5 had diarrhea

4 had appetite decrease

1 had mild abnormal liver function and 1 had dizziness. Symptoms of bilirubin increase

appetite decrease

mild abnormal liver function and dizziness gradually disappeared after drug withdrawal

three patients with severe diarrhea turned better after receiving Live combined bifidobacterium enteric-coated capsules. The average appearance time of bilirubin increase was 3. 50 ± 1. 05 days after treatment

and the appearance time of diarrhea was 2 days after treatment. CONCLUSIONS: Clinical pharmacists and physicians in medical institutions should pay more attention to and summarize the content of rational drug application

so as to provide reference for the revision of the "New Coronavirus Pneumonia Diagnosis and Treatment Scheme".

关键词

新型冠状病毒肺炎抗病毒药联合应用药品不良反应胆红素升高腹泻

Keywords

COVID-19Drug combination of antiviral agentsADRBilirubin increaseDiarrhea

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