Efficacy of Kanggan Granule Combined with Ribavirin in the Treatment of Hand Foot Mouth Disease in Children and its Effect on Immune Function and Inflammatory Factor

ZHAO Huaqing; LUO Xiaorong

doi:10.14009/j.issn.1672-2124.2020.10.004

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Efficacy of Kanggan Granule Combined with Ribavirin in the Treatment of Hand Foot Mouth Disease in Children and its Effect on Immune Function and Inflammatory Factor

更新时间：2022-10-08

- Efficacy of Kanggan Granule Combined with Ribavirin in the Treatment of Hand Foot Mouth Disease in Children and its Effect on Immune Function and Inflammatory Factor
- Vol. 20, Issue 10, Pages: 1168-1170(2020)
- 作者机构：
  
  1. 重庆三峡中心医院江南分院急诊科
  2. 重庆三峡中心医院江南分院门诊科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.10.004
  CLC： R725.1
- Published：2020，
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[1]赵华清,骆晓蓉.抗感颗粒联合利巴韦林治疗小儿手足口病的疗效及对免疫功能和炎症因子的影响[J].中国医院用药评价与分析,2020,20(10):1168-1170+1174.

ZHAO Huaqing, LUO Xiaorong. Efficacy of Kanggan Granule Combined with Ribavirin in the Treatment of Hand Foot Mouth Disease in Children and its Effect on Immune Function and Inflammatory Factor. [J]. 20(10):1168-1170(2020)
[1]赵华清,骆晓蓉.抗感颗粒联合利巴韦林治疗小儿手足口病的疗效及对免疫功能和炎症因子的影响[J].中国医院用药评价与分析,2020,20(10):1168-1170+1174. DOI： 10.14009/j.issn.1672-2124.2020.10.004.

ZHAO Huaqing, LUO Xiaorong. Efficacy of Kanggan Granule Combined with Ribavirin in the Treatment of Hand Foot Mouth Disease in Children and its Effect on Immune Function and Inflammatory Factor. [J]. 20(10):1168-1170(2020) DOI： 10.14009/j.issn.1672-2124.2020.10.004.

摘要

目的:探讨抗感颗粒联合利巴韦林治疗小儿手足口病（hand foot mouth disease

HFMD）的疗效及对免疫功能和炎症因子的影响。方法:选取2017年3月至2019年7月重庆三峡中心医院江南分院收治的小儿HFMD患者122例

采用随机数字表法分为对照组（n=61

采用利巴韦林治疗）和研究组（n=61

在对照组的基础上联合抗感颗粒治疗）。比较两组患儿症状改善时间、疗效、免疫功能（CD3+CD4+、CD3+CD8+、CD4+/CD8+）、炎症因子[可溶性细胞间黏附分子-1（s ICAM-1）、超敏C反应蛋白（hsCRP）和肿瘤坏死因子α（TNF-α）]水平及不良反应发生情况的差异。结果:研究组患儿食欲恢复时间、疱疹恢复时间、口腔溃疡消退时间及体温恢复时间明显短于对照组

差异均有统计学意义（P <0. 05）。研究组患儿治疗后的临床总有效率为95. 08%（58/61）

明显高于对照组的80. 33%（49/61）

差异有统计学意义（P <0. 05）。治疗后

两组患儿CD3+CD4+、CD4+/CD8+较治疗前明显升高

CD3+CD8+较治疗前明显降低;研究组患儿治疗后CD3+CD8+明显低于对照组

CD3+CD4+、CD4+/CD8+明显高于对照组

差异均有统计学意义（P <0. 05）。治疗后

两组患儿血清s ICAM-1、hs-CRP及TNF-α水平与治疗前相比均明显降低

且研究组患儿与对照组相比明显更低

差异均有统计学意义（P <0. 05）。研究组、对照组患儿的不良反应发生率分别为16. 39%（10/61）、14. 75%（9/61）

差异无统计学意义（χ2=0. 062

P=0. 803）。结论:抗感颗粒联合利巴韦林治疗小儿HFMD的疗效确切

患儿的临床症状和免疫功能可迅速被改善

炎症因子水平得到有效降低

且用药安全性较好。

Abstract

OBJECTIVE: To probe into the efficacy of Kanggan granule combined with ribavirin in the treatment of hand foot mouth disease（ HFMD） in children and its effect on immune function and inflammatory factors. METHODS:Totally 122 children with HFMD admitted into Jiangnan Branch of Chongqing Three Gorges Central Hospital from Mar.2017 to Jul. 2019 were selected and divided into control group（ 61 cases

treated with ribavirin） and research group（ 61 cases

given Kanggan granule combined with ribavirin） via random number table. Differences in symptom improvements

efficacy

immune function（ CD3+CD4+

CD3+CD8+

CD4+/CD8+）

inflammatory factor [solubility intercellular adhesion molecule-1（ s ICAM-1）

hypersensitivity C reactive protein（ hs-CRP） and tumor necrosis factor α（ TNF-α） ]level and incidences of adverse drug reactions were compared between two groups. RESULTS: The recovery times of appetite

herpes

oral ulcers and body temperature of the research group were significantly shorter than those of the control group

with statistically significant differences（ P < 0. 05）. The clinical total effective rate of research group was 95. 08%（ 58/61）

which was significantly higher than that of the control group（ 80. 33%

49/61）

with statistically significant difference（ P < 0. 05）. After treatment

the CD3+CD4+and CD4+/CD8 levels of both groups had been significantly increased

while the CD3+CD8+levels were significantly decreased; the CD3+CD8+levels of research group was significantly lower than those of the control group after treatment

while the CD3+CD4+and CD4+/CD8+levels were significantly higher than those of the control group

with statistically significant differences（ P <0. 05）. After treatment

the serum s ICAM-1

hs-CRP and TNF-α levels of both groups were significantly decreased

and those of the research group were significantly lower than the control group

with statistically significant differences（ P < 0. 05）. The incidences of adverse drug reactions of research group and control group were respectively16. 39%（ 10/61） and 14. 75%（ 9/61）

the difference had no statistical significance（ χ2= 0. 062

P = 0. 803）.CONCLUSIONS: The efficacy of Kanggan granule combined with ribavirin in the treatment of HFMD is remarkable

which can rapidly improve children’s clinical symptoms and immune function

reduce inflammatory factor level

with good medication safety.

关键词

抗感颗粒利巴韦林小儿手足口病疗效免疫功能炎症因子

Keywords

Kanggan granuleRibavirinHand foot mouth disease in childrenEfficacyImmune functionInflammatory factor

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