OBJECTIVE: To probe into the medication safety and blood concentration monitoring of vancomycin

so as to provide references for clinical rational medication. METHODS: 228 patients who were given vancomycin and conducted blood concentration monitoring in the Third Affiliated Hospital of Soochow University from 2018 to 2019 were selected as research object and analyzed the effects of age

basic renal function and drug configuration concentration on the blood concentration of vancomycin and renal function of patients. RESULTS: The blood concentration of vancomycin in 228 patients was monitored 394 case-times

of which 195 case-times （49. 49%） had reached the therapeutic window range （10-20 μg/ml）.The average blood concentration of vancomycin in patients aged between 60-70 was about 26. 75 μg/ml

and the proportion of patients aged > 70 with blood concentrations of vancomycin reaching the therapeutic window range was the highest

while the proprtion of patients aged <60 with blood concentration of vancomycin reaching toxic concentration was obviously the highest.Basic renal function could affect the blood concentration of vancomycin

the average blood concentration of vancomycin in patients with moderate to severe renal injury was about 27. 93 μg/ml

which was higher than the upper limit of therapeutic window. There was no statistical correlation between different configuration concentrations and blood concentration of vancomycin （P>0. 05）

and the configuration concentration had no effect on whether the blood concentration reached the standard. The differences in endogenous creatinine clearance rates and urea nitrogen levels before and after vancomycin treatment in patients with normal renal function were statistically significant （P<0. 05）; while there were no statistical significance in differences endogenous creatinine clearance rates and urea nitrogen levels before and after vancomycin treatment in patients with mild renal function and moderate to severe renal function （P>0. 05）.When the configuration concentration of vancomycin was >0. 5%

the differences in endogenous creatinine clearance rates and urea nitrogen levels before and after treatment were statistically significant （P < 0. 05）. When the blood concentration of vancomycin exceeds the therapeutic range

the difference in endogenous creatinine clearance rates before and after treatment was statistically significant （P<0. 05）.CONCLUSIONS: People age <60 years with normal basic renal function are also at risk of renal injury

during continuous use of vancomycin

the frequency of blood concentration monitoring should be increased

and pharmaceutical monitoring should be strengthened; excessively high vancomycin concentration can increase the risk of renal injury

so that clinical pharmacists need to make up for these careless omissions and assist physicians in medication monitoring of patients after using vancomycin.