Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with <sup>131</sup>I in the Treatment of Toxic Diffuse Goiter with Leucopenia

GUO Fei; HUANG Yunhui; NIU Huifang; ZHAO Zhekun; CHENG Zhe; WANG Shuo; CHEN Leiyin; GUO Zhengjun; WANG Lingjun; YANG Shichang

doi:10.14009/j.issn.1672-2124.2020.09.022

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Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with ¹³¹I in the Treatment of Toxic Diffuse Goiter with Leucopenia

更新时间：2022-10-08

- Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with ¹³¹I in the Treatment of Toxic Diffuse Goiter with Leucopenia
- Vol. 20, Issue 9, Pages: 1107-1111(2020)
- 作者机构：
  
  1. 新乡医学院第二附属医院药学部
  2. 新乡市第一人民医院风湿免疫科
  3. 新乡医学院药学院
  4. 新乡医学院第二附属医院精神科
  5. 新乡医学院第二附属医院防治科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.09.022
  CLC： R557.1;R581.3
- Published：2020，
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[1]郭飞,黄云慧,牛慧芳,赵喆堃,程哲,王硕,陈雷音,郭正军,王领军,杨世昌.碳酸锂联合~(131)I治疗毒性弥漫性甲状腺肿伴白细胞减少症疗效和安全性的系统评价[J].中国医院用药评价与分析,2020,20(09):1107-1111.

GUO Fei, HUANG Yunhui, NIU Huifang, et al. Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with ¹³¹I in the Treatment of Toxic Diffuse Goiter with Leucopenia. [J]. 20(9):1107-1111(2020)
[1]郭飞,黄云慧,牛慧芳,赵喆堃,程哲,王硕,陈雷音,郭正军,王领军,杨世昌.碳酸锂联合~(131)I治疗毒性弥漫性甲状腺肿伴白细胞减少症疗效和安全性的系统评价[J].中国医院用药评价与分析,2020,20(09):1107-1111. DOI： 10.14009/j.issn.1672-2124.2020.09.022.

GUO Fei, HUANG Yunhui, NIU Huifang, et al. Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with ¹³¹I in the Treatment of Toxic Diffuse Goiter with Leucopenia. [J]. 20(9):1107-1111(2020) DOI： 10.14009/j.issn.1672-2124.2020.09.022.

摘要

目的:系统评价碳酸锂联合

131

I对毒性弥漫性甲状腺肿伴白细胞减少症的疗效和安全性。方法:计算机检索the Cochrane Library、PubMed、万方数据库、中国知网及维普数据库

辅以网络检索和手工检索

收集有关碳酸锂联合

131

I治疗毒性弥漫性甲状腺肿伴白细胞减少症的临床研究(观察组患者采用碳酸锂与

131

I联合治疗;对照组患者单纯采用

131

I治疗)

对纳入的研究采用Rev Man 5.3软件进行荟萃分析（Meta分析）。结果:共纳入5篇文献

涉及777例患者。Meta分析结果显示

观察组患者的血清游离三碘甲状腺原氨酸（FT

）水平在联合用药后15 d（MD=-17.85

95%CI=-21.79～-13.91

0.000 01）、30 d（MD=-16.21

95%CI=-29.62～-2.80

P=0.02）和90 d（MD=-3.14

95%CI=-5.34～-0.93

P=0.005）均明显低于对照组

差异均有统计学意义;观察组患者的血清游离甲状腺素（FT

）水平在联合用药后15 d（MD=-18.09

95%CI=-22.78～-13.41

0.000 01）、30 d（MD=-20.67

95%CI=-32.56～-8.78

P=0.000 7）和90 d（MD=-7.64

95%CI=-12.18～-3.09

P=0.001）均明显低于对照组

差异均有统计学意义;观察组患者的白细胞计数（WBC）在联合用药后15 d（MD=0.56

95%CI=0.25～0.88

P=0.000 4）、30 d（MD=0.72

95%CI=0.38～1.07

0.000 1）均明显高于对照组

差异均有统计学意义

而在联合用药后90 d时与对照组的差异无统计学意义（MD=1.12

95%CI=-0.05～2.28

P=0.06）。结论:碳酸锂联合

131

I可有效降低毒性弥漫性甲状腺肿伴白细胞减少症患者的FT

和FT

水平

并可升高患者的WBC水平。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of lithium carbonate combined with

131

I in the treatment of toxic diffuse goiter with leucopenia. METHODS: PubMed

the Cochrane Library

CNKI

Wanfang database and VIP database were retrieved by computer

and supplemented by online and manual search

clinical studies of lithium carbonate combined with

131

I in the treatment of toxic diffuse goiter with leucopenia (the observation group was treated with lithium carbonate combined with

131

while the control group received

131

I alone) were collected. Meta-analysis was performed on the included studies by using RevMan 5. 3 software. RESULTS: Totally 5 literature were collected

including 777 patients. Meta-analysis results showed that the serum levels of free triiodothylamine （FT

） in the observation group were significantly lower than those in the control group at 15 d （MD=-17. 85

95%CI =-21. 79--13. 91

0. 000 01）

30 d （MD =-16. 21

95% CI =-29. 62--2. 80

P = 0. 02） and 90 d （MD=-3. 14

95% CI =-5. 34--0. 93

P = 0. 005） after drug combination

and the differences were statistically significant. The serum levels of free thyroxine （FT

） in the observation group were significantly lower than those in the control group at 15 d （MD =-18. 09

95%CI =-22. 78--13. 41

0. 000 01）

30 d （MD =-20. 67

95%CI =-32. 56--8. 78

P = 0. 000 7） and 90 d （MD =-7. 64

95% CI =-12. 18--3. 09

P = 0. 001） after drug combination

and the differences were statistically significant. The white blood cell count （WBC） of the observation group was significantly higher than that of the control group at 15 d （MD = 0. 56

95% CI = 0. 25-0. 88

P = 0. 000 4） and 30 d （MD = 0. 72

95%CI = 0. 38-1. 07

0. 000 1）

while there was no statistically significant difference between two groups at 90 d （MD= 1. 12

95%CI=-0. 05-2. 28

P = 0. 06）. CONCLUSIONS: Lithium carbonate combined with

131

I can effectively reduce the levels of FT

and FT

and increase the levels of WBC in patients with toxic diffuse goiter associated with leucopenia.

关键词

碳酸锂131I毒性弥漫性甲状腺肿白细胞减少症Meta分析

Keywords

Lithium carbonate131IToxic diffuse goiterLeucopeniaMeta-analysis

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⁰

Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with 131I in the Treatment of Toxic Diffuse Goiter with Leucopenia

DOI：10.14009/j.issn.1672-2124.2020.09.022

摘要

Abstract

关键词

Keywords

references

Systematic Review of Efficacy and Safety of Lithium Carbonate Combined with ¹³¹I in the Treatment of Toxic Diffuse Goiter with Leucopenia