Evidence-Based Review of Xingnaojing Injection in the Auxiliary Treatment of Consciousness Disturbance Induced by Systemic Diseases

ZHANG Yan; MEN Peng; DONG Huan; LI Xiaotong; ZHAI Suodi; ZHAO Rongsheng; YANG Yiheng

doi:10.14009/j.issn.1672-2124.2020.09.021

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Evidence-Based Review of Xingnaojing Injection in the Auxiliary Treatment of Consciousness Disturbance Induced by Systemic Diseases

更新时间：2022-10-08

- Evidence-Based Review of Xingnaojing Injection in the Auxiliary Treatment of Consciousness Disturbance Induced by Systemic Diseases
- Vol. 20, Issue 9, Pages: 1103-1106(2020)
- 作者机构：
  
  1. 北京大学第三医院药剂科
  2. 北京大学医学部药物评价中心
  3. 北京市药学质量控制和改进中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.09.021
  CLC： R277.7
- Published：2020，
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[1]张妍,门鹏,董环,李晓通,翟所迪,赵荣生,杨毅恒.醒脑静注射液辅助治疗全身性疾病所致意识障碍的循证评价[J].中国医院用药评价与分析,2020,20(09):1103-1106.

ZHANG Yan, MEN Peng, DONG Huan, et al. Evidence-Based Review of Xingnaojing Injection in the Auxiliary Treatment of Consciousness Disturbance Induced by Systemic Diseases. [J]. 20(9):1103-1106(2020)
[1]张妍,门鹏,董环,李晓通,翟所迪,赵荣生,杨毅恒.醒脑静注射液辅助治疗全身性疾病所致意识障碍的循证评价[J].中国医院用药评价与分析,2020,20(09):1103-1106. DOI： 10.14009/j.issn.1672-2124.2020.09.021.

ZHANG Yan, MEN Peng, DONG Huan, et al. Evidence-Based Review of Xingnaojing Injection in the Auxiliary Treatment of Consciousness Disturbance Induced by Systemic Diseases. [J]. 20(9):1103-1106(2020) DOI： 10.14009/j.issn.1672-2124.2020.09.021.

摘要

目的:基于文献

评价醒脑静注射液辅助治疗全身性疾病所致意识障碍患者的临床效果

为临床实践提供循证依据。方法:计算机检索the Cochrane Library、Pubmed、万方数据库、中国知网和中国生物医学文献服务系统

收集醒脑静注射液治疗全身性疾病所致意识障碍患者的系统评价/荟萃分析（Meta分析）

由2名评价者严格按照纳入与排除标准筛选文献、提取相关资料并评价文献质量后

对相关证据进行综合梳理与分析。结果:共纳入5篇文献

均为系统评价/Meta分析

总体质量中等。在治疗一氧化碳中毒、肝性脑病、酒精中毒以及肺性脑病所致的意识障碍方面

与单纯应用常规治疗比较

联合醒脑静注射液治疗可明显提高治疗有效率

缩短中毒患者苏醒时间

缩短酒精中毒患者症状消失时间

改善动脉氧分压、二氧化碳分压水平

差异均有统计学意义（P<0.05）。结论:醒脑静注射液辅助治疗全身性疾病所致意识障碍

可进一步提高临床疗效

但仍需高质量的临床研究对其安全性及与其他阳性药物的效果比较进行分析。

Abstract

OBJECTIVE: To evaluate the clinical efficacy of Xingnaojing injection in the auxiliary treatment of consciousness disturbance induced by systemic diseases

so as to provide evidence-based references for clinical practice. METHODS: The Cochrane Library

Pub Med

Wanfang

CNKI and Sinomed databases were systematically retrieved to collect systematic review/meta-analysis of Xingnaojing injection in the treatment of consciousness disturbance. After two reviewers screened the literature according to the inclusion and exclusion criteria

extracted the data and evaluated the quality

the evidence was comprehensively analyzed. RESULTS: A total of 5 literature were included

all of which were systematic review/meta-analysis

with medium overall quality. In the treatment of consciousness disturbance induced by carbon monoxide poisoning

hepatic encephalopathy

alcoholism and pulmonary encephalopathy

compared with conventional treatment alone

the combined application of Xingnaojing injection can significantly increase the effective rate of treatment and shorten the recovery time of poisoned patients

shorten the disappearance time of symptoms of alcoholism patients and improve the arterial partial pressure of oxygen and carbon dioxide

the differences were statistically significant（ P < 0. 05）. CONCLUSIONS: Xingnaojing injection in the auxiliary treatment of consciousness disturbance induced by systemic diseases can further improve the clinical efficacy.However

further clinical studies should be performed to clarify the safety profiles and comparative effectiveness among other active comparators.

关键词

醒脑静注射液意识障碍一氧化碳中毒肝性脑病酒精中毒肺性脑病循证评价

Keywords

Xingnaojing injectionConsciousness disturbanceCarbon monoxide poisoningHepatic encephalopathyAlcoholismPulmonary encephalopathyEvidence-based review

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