Efficacy of Guanxinshutong Capsule Combined with Metoprolol in the Treatment of Unstable Angina Pectoris and its Effects on Hemorheology and Inflammatory Factors

GOU Weihua; ZHANG Dan

doi:10.14009/j.issn.1672-2124.2020.09.013

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Efficacy of Guanxinshutong Capsule Combined with Metoprolol in the Treatment of Unstable Angina Pectoris and its Effects on Hemorheology and Inflammatory Factors

更新时间：2022-10-08

- Efficacy of Guanxinshutong Capsule Combined with Metoprolol in the Treatment of Unstable Angina Pectoris and its Effects on Hemorheology and Inflammatory Factors
- Vol. 20, Issue 9, Pages: 1075-1077(2020)
- 作者机构：
  
  庆阳市人民医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.09.013
  CLC： R541.4
- Published：2020，
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[1]勾韦华,张丹.冠心舒通胶囊联合美托洛尔治疗不稳定型心绞痛的疗效及对血液流变学、炎症因子的影响[J].中国医院用药评价与分析,2020,20(09):1075-1077+1082.

GOU Weihua, ZHANG Dan. Efficacy of Guanxinshutong Capsule Combined with Metoprolol in the Treatment of Unstable Angina Pectoris and its Effects on Hemorheology and Inflammatory Factors. [J]. 20(9):1075-1077(2020)
[1]勾韦华,张丹.冠心舒通胶囊联合美托洛尔治疗不稳定型心绞痛的疗效及对血液流变学、炎症因子的影响[J].中国医院用药评价与分析,2020,20(09):1075-1077+1082. DOI： 10.14009/j.issn.1672-2124.2020.09.013.

GOU Weihua, ZHANG Dan. Efficacy of Guanxinshutong Capsule Combined with Metoprolol in the Treatment of Unstable Angina Pectoris and its Effects on Hemorheology and Inflammatory Factors. [J]. 20(9):1075-1077(2020) DOI： 10.14009/j.issn.1672-2124.2020.09.013.

摘要

目的:探讨冠心舒通胶囊联合美托洛尔治疗不稳定型心绞痛（unstable angina pectoris

UAP）的疗效及对血液流变学、炎症因子的影响。方法:纳入2017年6月至2019年6月就诊于庆阳市人民医院的UAP患者300例

按照随机数字表法分为观察组和对照组

每组150例。对照组患者口服美托洛尔

观察组患者在此基础上加用冠心舒通胶囊

两组患者均连续治疗4周。观察两组患者的临床疗效、不良反应发生情况

症状、血液流变学指标及炎症因子[肿瘤坏死因子α（TNF-α）、超敏C反应蛋白（hs-CRP）和髓过氧化物酶（MPO）]水平的变化。结果:观察组患者的总有效率为90.67%（136/150）

明显高于对照组的77.33%（116/150）

差异有统计学意义（χ

=9.921

P=0.002）。与治疗前相比

两组患者治疗后心绞痛发作次数减少

症状持续时间缩短

心绞痛VAS评分降低

且观察组患者治疗后上述指标改善情况明显优于对照组同期

差异均有统计学意义（P

0.05）;治疗后

两组患者全血黏度、血浆比黏度、红细胞压积水平及血清炎症因子（TNF-α、hs-CRP和MPO）水平均较治疗前明显降低

且观察组患者明显低于对照组

差异均有统计学意义（P

0.05）。观察组患者的不良反应发生率为6.67%（10/150）

明显低于对照组的15.33%（23/150）

差异有统计学意义（χ

=5.754

P=0.016）。结论:冠心舒通胶囊联合美托洛尔治疗UAP的疗效显著

可以明显改善患者的临床症状及血液流变学指标

降低炎症因子水平

减少不良反应。

Abstract

OBJECTIVE: To probe into the efficacy of Guanxinshutong capsule combined with metoprolol in the treatment of unstable angina pectoris （UAP） and its effects on hemorheology and inflammatory factors. METHODS:Totally 300 patients with UAP admitted into Qingyang People’s Hospital from Jun. 2017 to Jun. 2019 were selected and divided into observation group and control group via random number table

with 150 cases in each group. The control group was given metoprolol orally

while the observation group was given Guanxinshutong capsule on this basis

both groups were treated continuously for 4 weeks. The clinical efficacy and incidences of adverse reactions

changes of symptoms

hemorheological indicators and inflammatory factors [tumor necrosis factor α （TNF-α）

high-sensitivity Creactive protein （hs-CRP） and myeloperoxidase （MPO） ]of both groups were observed. RESULTS: The total effective rate of observation group was 90. 67% （136/150）

which was significantly higher than that of the control group （77. 33%

116/150）

with statistically significant difference （χ

= 9. 921

P = 0. 002）. Compared with before treatment

the frequency of UA reduced

the duration of shortened and VAS scores of UA decreased in both groups after treatment

and the improvements of the above indicators of observation group were significantly better than those of the control group

with statistically significant differences （P

0. 05）; after treatment

the whole blood viscosity

plasma viscosity ratio

hematokrit levels and serum inflammatory factor （TNF-α

hs-CRP and MPO） levels of both groups significantly decreased

and those of the observation group were significantly lower than the control group

with statistically significant differences （P

0. 05）. The incidence of adverse reactions of observation group was 6. 67% （10/150）

which was significantly lower than that of the control group （15. 33%

23/150）

with statistically significant difference （χ

= 5. 754

P = 0. 016）. CONCLUSIONS: The efficacy of Guanxinshutong capsule combined with metoprolol in the treatment of UAP is remarkable

which can significantly improve clinical symptoms and hemorheological indicators

reduce inflammatory factor levels and adverse reactions.

关键词

冠心舒通胶囊美托洛尔不稳定型心绞痛临床疗效炎症因子

Keywords

Guanxinshutong capsuleMetoprololUnstable angina pectorisClinical efficacyInflammatory factor

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