Efficacy of Tanshinone ⅡA Sodium Sulfonate Injection Combined with Bailing Capsule in the Treatment of Chronic Renal Failure and its Effect on Renal Function and Renal Fibrosis Index

XIE Sheng; YANG Yongchao; DENG Xiangjun

doi:10.14009/j.issn.1672-2124.2020.09.010

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Efficacy of Tanshinone ⅡA Sodium Sulfonate Injection Combined with Bailing Capsule in the Treatment of Chronic Renal Failure and its Effect on Renal Function and Renal Fibrosis Index

更新时间：2022-10-08

- Efficacy of Tanshinone ⅡA Sodium Sulfonate Injection Combined with Bailing Capsule in the Treatment of Chronic Renal Failure and its Effect on Renal Function and Renal Fibrosis Index
- Vol. 20, Issue 9, Pages: 1063-1066(2020)
- 作者机构：
  
  1. 溧阳市人民医院肾内科
  2. 宝鸡市中医院肾内科
  3. 常州市中医院肾内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.09.010
  CLC： R692.5
- Published：2020，
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[1]谢胜,杨永超,邓祥军.丹参酮ⅡA磺酸钠注射液联合百令胶囊治疗慢性肾衰竭的疗效及对肾功能、肾纤维化指标的影响[J].中国医院用药评价与分析,2020,20(09):1063-1066.

XIE Sheng, YANG Yongchao, DENG Xiangjun. Efficacy of Tanshinone ⅡA Sodium Sulfonate Injection Combined with Bailing Capsule in the Treatment of Chronic Renal Failure and its Effect on Renal Function and Renal Fibrosis Index. [J]. 20(9):1063-1066(2020)
[1]谢胜,杨永超,邓祥军.丹参酮ⅡA磺酸钠注射液联合百令胶囊治疗慢性肾衰竭的疗效及对肾功能、肾纤维化指标的影响[J].中国医院用药评价与分析,2020,20(09):1063-1066. DOI： 10.14009/j.issn.1672-2124.2020.09.010.

XIE Sheng, YANG Yongchao, DENG Xiangjun. Efficacy of Tanshinone ⅡA Sodium Sulfonate Injection Combined with Bailing Capsule in the Treatment of Chronic Renal Failure and its Effect on Renal Function and Renal Fibrosis Index. [J]. 20(9):1063-1066(2020) DOI： 10.14009/j.issn.1672-2124.2020.09.010.

摘要

目的:探讨丹参酮ⅡA磺酸钠注射液联合百令胶囊治疗慢性肾衰竭的临床疗效及对肾功能、肾纤维化指标的影响。方法:选取2017年10月至2019年10月溧阳市人民医院收治的慢性肾衰竭患者105例

按随机数字表法分为对照组52例和治疗组53例。两组患者均给予常规治疗

对照组患者在常规治疗的基础上给予百令胶囊

治疗组患者在常规治疗的基础上给予丹参酮ⅡA磺酸钠注射液联合百令胶囊

两组患者均连续治疗2个月。比较两组患者治疗前后的白细胞介素6（IL-6）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、血肌酐（SCr）、尿素氮（BUN）、24 h尿蛋白定量（24 h UPQ）、转化生长因子β（TGF-β）、结缔组织生长因子（CTGF）及Ⅳ型胶原（Col-Ⅳ）水平的差异

记录两组患者的临床疗效及治疗过程中的不良反应发生情况。结果:治疗组患者的总有效率为86.79%（46/53）

明显高于对照组的69.23%（36/52）

差异有统计学意义（P<0.05）。治疗后

两组患者IL-6、hs-CRP、TNF-α、SCr、BUN、24 h UPQ、TGF-β、CTGF及Col-Ⅳ水平明显低于治疗前

且治疗组患者明显低于对照组

差异均有统计学意义（P<0.05）。对照组、治疗组患者的不良反应发生率分别为9.6%（5/52）、11.3%（6/53）

差异无统计学意义（P>0.05）。结论:丹参酮ⅡA磺酸钠注射液联合百令胶囊治疗慢性肾衰竭的临床疗效显著

能够抑制患者的微炎症反应

改善肾功能

延缓肾纤维化

且安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of tanshinone ⅡA sodium sulfonate injection combined with Bailing capsule in the treatment of chronic renal failure and its effect on renal function and renal fibrosis index.METHODS: Totally 105 patients with chronic renal failure admitted into Liyang People’s Hospital from Oct. 2017 to Oct. 2019 were selected and divided into control group （52 cases） and treatment group （53 cases） via random number table. Both groups were given conventional therapy

the control group treated with Bailing capsule based on conventional therapy

while the treatment group was given tanshinone ⅡA sodium sulfonate injection combined with Bailing capsule based on conventional therapy

both groups were treated continuously for 2 months. Differences in interleukin-6 （IL-6）

high-sensitivity C-reactive protein （hs-CRP）

tumor necrosis factor α （TNF-α）

serum creatinine （SCr）

blood urea nitrogen （BUN）

urine protein quantitation in 24 h （24 h UPQ）

transforming growth factor β （TGF-β）

connective tissue growth factor （CTGF） and IV-type collagen （Col-IV） between two groups before and after treatment were compared

the clinical efficacy and incidences of adverse drug reactions of both groups were recorded. RESULTS: The total effective rate of treatment group was 86. 79% （46/53）

which was significantly higher than that of the control group （69. 23%

36/52）

with statistically significant difference （P<0. 05）. After treatment

the IL-6

hs-CRP

TNF-α

SCr

BUN

24 h UPQ

TGF-β

CTGF and Col-Ⅳ levels of both groups had been significantly decreased

and those of treatment group were significantly lower than the control group

with statistically significant differences （P<0. 05）. The incidences of adverse drug reactions of control group and treatment group were respectively 9. 6% （5/52） and 11. 3% （6/53）

the difference had no statistical significance （P > 0. 05）.CONCLUSIONS: The efficacy of tanshinone ⅡA sodium sulfonate injection combined with Bailing capsule in the treatment of chronic renal failure is remarkable

which can significantly inhibit micro-inflammatory reaction

improve renal function and postpone renal fibrosis

with high safety.

关键词

慢性肾衰竭丹参酮ⅡA磺酸钠注射液百令胶囊疗效

Keywords

Chronic renal failureTanshinone ⅡA sodium sulfonate injectionBailing capsuleEfficacy

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