Application Status of Model-based Meta-analysis in Evaluation of Efficacy of Hypoglycemic Drugs

YAN Kaicheng; CAI Yun; WANG Rui

doi:10.14009/j.issn.1672-2124.2020.08.033

您当前的位置：

首页 >

文章列表页 >

Application Status of Model-based Meta-analysis in Evaluation of Efficacy of Hypoglycemic Drugs

更新时间：2022-10-08

- Application Status of Model-based Meta-analysis in Evaluation of Efficacy of Hypoglycemic Drugs
- Vol. 20, Issue 8, Pages: 1020-1024(2020)
- 作者机构：
  
  中国人民解放军总医院医疗保障中心药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.08.033
  CLC： R977.15
- Published：2020，
扫描看全文
[1]闫开成,蔡芸,王睿.基于模型的Meta分析方法在抗糖尿病药疗效评价中的应用现状[J].中国医院用药评价与分析,2020,20(08):1020-1024.

YAN Kaicheng, CAI Yun, WANG Rui. Application Status of Model-based Meta-analysis in Evaluation of Efficacy of Hypoglycemic Drugs. [J]. 20(8):1020-1024(2020)
[1]闫开成,蔡芸,王睿.基于模型的Meta分析方法在抗糖尿病药疗效评价中的应用现状[J].中国医院用药评价与分析,2020,20(08):1020-1024. DOI： 10.14009/j.issn.1672-2124.2020.08.033.

YAN Kaicheng, CAI Yun, WANG Rui. Application Status of Model-based Meta-analysis in Evaluation of Efficacy of Hypoglycemic Drugs. [J]. 20(8):1020-1024(2020) DOI： 10.14009/j.issn.1672-2124.2020.08.033.

摘要

基于模型的Meta分析（model-based meta-analysis

MBMA）是一个定量的药理学方法

其基于既往临床研究数据

建立药效学模型和统计学模型

并引入协变量来预测药物疗效。MBMA可以为2型糖尿病治疗药物的选择提供有效方法

建立模型对各类抗糖尿病药在血糖控制、体重变化和低血糖风险等方面进行比较分析

对不同给药剂量和治疗间期进行模拟和预测

为临床医师针对不同患者进行个体化治疗提供依据。

Abstract

Model-based meta-analysis（MBMA） is a type of quantitative pharmacological method.Based on the previous clinical research data

pharmacodynamic model and statistical model are established

and covariates are introduced to predict the drug efficacy.MBMA can provide an effective method for the selection of treatment drugs for type 2 diabetes mellitus

establish a model to compare and analyze various hypoglycemic drugs in the aspects of blood glucose control

weight change and hypoglycemia risk

simulate and predict different dosage and treatment interval

so as to improve the basis for specialists to carry out individualized treatment in different patients.

关键词

基于模型的Meta分析药效学模型2型糖尿病抗糖尿病药

Keywords

Model-based meta-analysisPharmacodynamic modelType 2 diabetes mellitusHypoglycemic drugs

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application Rationality of Antidiabetic Drugs in 100 Inpatients with Type 2 Diabetes Mellitus in One Class Ⅲ Grade A Hospital

Systematic Review of Efficacy and Safety of Semaglutide in the Treatment of Type 2 Diabetes Mellitus

Effects of Alprostadil Combined with Insulin Degludec in the Treatment of Lower Extremity Vascular Disease with Type 2 Diabetes Mellitus Based on Balance of Oxidation/Antioxidation and Changes of miR-221 and miR-155 Levels

Effect of Dangua Humai Oral Liquid on Vascular Endothelial Function and Oxidative Stress Indicators in Patients with Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease

Analysis of Compliance with Guidelines for the Use of Statins in 1 168 Patients with Type 2 Diabetes Mellitus in Endocrinology Department

Related Author

LI Pingping

ZHANG Yahui

ZHANG Chao

NIE Ruifang

GE Lanlan

YU Hengcai

ZENG Fang

HU Jinhua

Related Institution

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

Dept. of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University

School of Pharmacy, Shandong First Medical University

Quality Control and Performance Management Office, Shandong Provincial Hospital Affiliated to Shandong First Medical University

Dept.of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University

⁰